Challenges and prospects for the control of foot-and-mouth disease: an African perspective

Francois F Maree,1,2 Christopher J Kasanga,3, Katherine A Scott,1 Pamela A Opperman,1,2 Melanie Chitray,1,2, Abraham K Sangula,4 Raphael Sallu,3 Yona Sinkala,5 Philemon N Wambura,3 Donald P King,6 David J Paton,6 Mark M Rweyemamu,3 1Transboundary Animal Diseases Programme, Onderstepoort Veterinary...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maree FF, Kasanga CJ, Scott KA, Opperman PA, Chitray M, Sangula AK, Sallu R, Sinkala Y, Wambura PN, King DP, Paton DJ, Rweyemamu MM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b3606fead4474245bd71d3abf0dd2dc2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b3606fead4474245bd71d3abf0dd2dc2
record_format	dspace
spelling	oai:doaj.org-article:b3606fead4474245bd71d3abf0dd2dc22021-12-02T02:07:49ZChallenges and prospects for the control of foot-and-mouth disease: an African perspective2230-2034https://doaj.org/article/b3606fead4474245bd71d3abf0dd2dc22014-10-01T00:00:00Zhttp://www.dovepress.com/challenges-and-prospects-for-the-control-of-foot-and-mouth-disease-an--peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034 Francois F Maree,1,2 Christopher J Kasanga,3, Katherine A Scott,1 Pamela A Opperman,1,2 Melanie Chitray,1,2, Abraham K Sangula,4 Raphael Sallu,3 Yona Sinkala,5 Philemon N Wambura,3 Donald P King,6 David J Paton,6 Mark M Rweyemamu,3 1Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, Pretoria, South Africa; 2Department of Microbiology and Plant Pathology, Faculty of Agricultural and Natural Sciences, University of Pretoria, Pretoria, South Africa; 3Southern African Centre for Infectious Diseases Surveillance, Sokoine University of Agriculture, Morogoro, Tanzania; 4Foot-and-Mouth Disease Laboratory, Embakasi, Nairobi, Kenya; 5Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia; 6The Pirbright Institute, Pirbright, Surrey, UK Abstract: The epidemiology of foot-and-mouth disease (FMD) in Africa is unique in the sense that six of the seven serotypes of FMD viruses (Southern African Territories [SAT] 1, SAT2, SAT3, A, O, and C), with the exception of Asia-1, have occurred in the last decade. Due to underreporting of FMD, the current strains circulating throughout sub-Saharan Africa are in many cases unknown. For SAT1, SAT2, and serotype A viruses, the genetic diversity is reflected in antigenic variation, and indications are that vaccine strains may be needed for each topotype. This has serious implications for control using vaccines and for choice of strains to include in regional antigen banks. The epidemiology is further complicated by the fact that SAT1, SAT2, and SAT3 viruses are maintained and spread by wildlife, persistently infecting African buffalo in particular. Although the precise mechanism of transmission of FMD from buffalo to cattle is not well understood, it is facilitated by direct contact between these two species. Once cattle are infected they may maintain SAT infections without the further involvement of buffalo. No single strategy for control of FMD in Africa is applicable. Decision on the most effective regional control strategy should focus on an ecosystem approach, identification of primary endemic areas, animal husbandry practices, climate, and animal movement. Within each ecosystem, human behavior could be integrated in disease control planning. Different regions in sub-Saharan Africa are at different developmental stages and are thus facing unique challenges and priorities in terms of veterinary disease control. Many science-based options targeting improved vaccinology, diagnostics, and other control measures have been described. This review therefore aims to emphasize, on one hand, the progress that has been achieved in the development of new technologies, including research towards improved tailored vaccines, appropriate vaccine strain selection, vaccine potency, and diagnostics, and how it relates to the conditions in Africa. On the other hand, we focus on the unique epidemiological, ecological, livestock farming and marketing, socioeconomic, and governance issues that constrain effective FMD control. Any such new technologies should have the availability of safe livestock products for trade as the ultimate goal.Keywords: vaccine, foot-and-mouth disease virus, vaccine matching, new-generation vaccine, diagnostic testsMaree FFKasanga CJScott KAOpperman PAChitray MSangula AKSallu RSinkala YWambura PNKing DPPaton DJRweyemamu MMDove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2014, Iss default, Pp 119-138 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Maree FF Kasanga CJ Scott KA Opperman PA Chitray M Sangula AK Sallu R Sinkala Y Wambura PN King DP Paton DJ Rweyemamu MM Challenges and prospects for the control of foot-and-mouth disease: an African perspective
description	Francois F Maree,1,2 Christopher J Kasanga,3, Katherine A Scott,1 Pamela A Opperman,1,2 Melanie Chitray,1,2, Abraham K Sangula,4 Raphael Sallu,3 Yona Sinkala,5 Philemon N Wambura,3 Donald P King,6 David J Paton,6 Mark M Rweyemamu,3 1Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, Pretoria, South Africa; 2Department of Microbiology and Plant Pathology, Faculty of Agricultural and Natural Sciences, University of Pretoria, Pretoria, South Africa; 3Southern African Centre for Infectious Diseases Surveillance, Sokoine University of Agriculture, Morogoro, Tanzania; 4Foot-and-Mouth Disease Laboratory, Embakasi, Nairobi, Kenya; 5Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia; 6The Pirbright Institute, Pirbright, Surrey, UK Abstract: The epidemiology of foot-and-mouth disease (FMD) in Africa is unique in the sense that six of the seven serotypes of FMD viruses (Southern African Territories [SAT] 1, SAT2, SAT3, A, O, and C), with the exception of Asia-1, have occurred in the last decade. Due to underreporting of FMD, the current strains circulating throughout sub-Saharan Africa are in many cases unknown. For SAT1, SAT2, and serotype A viruses, the genetic diversity is reflected in antigenic variation, and indications are that vaccine strains may be needed for each topotype. This has serious implications for control using vaccines and for choice of strains to include in regional antigen banks. The epidemiology is further complicated by the fact that SAT1, SAT2, and SAT3 viruses are maintained and spread by wildlife, persistently infecting African buffalo in particular. Although the precise mechanism of transmission of FMD from buffalo to cattle is not well understood, it is facilitated by direct contact between these two species. Once cattle are infected they may maintain SAT infections without the further involvement of buffalo. No single strategy for control of FMD in Africa is applicable. Decision on the most effective regional control strategy should focus on an ecosystem approach, identification of primary endemic areas, animal husbandry practices, climate, and animal movement. Within each ecosystem, human behavior could be integrated in disease control planning. Different regions in sub-Saharan Africa are at different developmental stages and are thus facing unique challenges and priorities in terms of veterinary disease control. Many science-based options targeting improved vaccinology, diagnostics, and other control measures have been described. This review therefore aims to emphasize, on one hand, the progress that has been achieved in the development of new technologies, including research towards improved tailored vaccines, appropriate vaccine strain selection, vaccine potency, and diagnostics, and how it relates to the conditions in Africa. On the other hand, we focus on the unique epidemiological, ecological, livestock farming and marketing, socioeconomic, and governance issues that constrain effective FMD control. Any such new technologies should have the availability of safe livestock products for trade as the ultimate goal.Keywords: vaccine, foot-and-mouth disease virus, vaccine matching, new-generation vaccine, diagnostic tests
format	article
author	Maree FF Kasanga CJ Scott KA Opperman PA Chitray M Sangula AK Sallu R Sinkala Y Wambura PN King DP Paton DJ Rweyemamu MM
author_facet	Maree FF Kasanga CJ Scott KA Opperman PA Chitray M Sangula AK Sallu R Sinkala Y Wambura PN King DP Paton DJ Rweyemamu MM
author_sort	Maree FF
title	Challenges and prospects for the control of foot-and-mouth disease: an African perspective
title_short	Challenges and prospects for the control of foot-and-mouth disease: an African perspective
title_full	Challenges and prospects for the control of foot-and-mouth disease: an African perspective
title_fullStr	Challenges and prospects for the control of foot-and-mouth disease: an African perspective
title_full_unstemmed	Challenges and prospects for the control of foot-and-mouth disease: an African perspective
title_sort	challenges and prospects for the control of foot-and-mouth disease: an african perspective
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b3606fead4474245bd71d3abf0dd2dc2
work_keys_str_mv	AT mareeff challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT kasangacj challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT scottka challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT oppermanpa challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT chitraym challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT sangulaak challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT sallur challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT sinkalay challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT wamburapn challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT kingdp challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT patondj challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective AT rweyemamumm challengesandprospectsforthecontroloffootandmouthdiseaseanafricanperspective
_version_	1718402671338061824

Challenges and prospects for the control of foot-and-mouth disease: an African perspective

Ejemplares similares