The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions
Binding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regulator for Env transitions.
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Nature Portfolio
2017
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oai:doaj.org-article:b36161e14e3f46feaa6eadd812d25c742021-12-02T15:38:55ZThe β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions10.1038/s41467-017-01119-w2041-1723https://doaj.org/article/b36161e14e3f46feaa6eadd812d25c742017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01119-whttps://doaj.org/toc/2041-1723Binding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regulator for Env transitions.Alon HerschhornChristopher GuFrancesca MoracaXiaochu MaMark FarrellAmos B. SmithMarie PanceraPeter D. KwongArne SchönErnesto FreireCameron AbramsScott C. BlanchardWalther MothesJoseph G. SodroskiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Alon Herschhorn Christopher Gu Francesca Moraca Xiaochu Ma Mark Farrell Amos B. Smith Marie Pancera Peter D. Kwong Arne Schön Ernesto Freire Cameron Abrams Scott C. Blanchard Walther Mothes Joseph G. Sodroski The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| description |
Binding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regulator for Env transitions. |
| format |
article |
| author |
Alon Herschhorn Christopher Gu Francesca Moraca Xiaochu Ma Mark Farrell Amos B. Smith Marie Pancera Peter D. Kwong Arne Schön Ernesto Freire Cameron Abrams Scott C. Blanchard Walther Mothes Joseph G. Sodroski |
| author_facet |
Alon Herschhorn Christopher Gu Francesca Moraca Xiaochu Ma Mark Farrell Amos B. Smith Marie Pancera Peter D. Kwong Arne Schön Ernesto Freire Cameron Abrams Scott C. Blanchard Walther Mothes Joseph G. Sodroski |
| author_sort |
Alon Herschhorn |
| title |
The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_short |
The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_full |
The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_fullStr |
The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_full_unstemmed |
The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_sort |
β20–β21 of gp120 is a regulatory switch for hiv-1 env conformational transitions |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/b36161e14e3f46feaa6eadd812d25c74 |
| work_keys_str_mv |
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1718386068897660928 |