Optical signatures of radiofrequency ablation in biological tissues

Abstract Accurate monitoring of treatment is crucial in minimally-invasive radiofrequency ablation in oncology and cardiovascular disease. We investigated alterations in optical properties of ex-vivo bovine tissues of the liver, heart, muscle, and brain, undergoing the treatment. Time-domain diffuse...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pranav Lanka, Kalloor Joseph Francis, Hindrik Kruit, Andrea Farina, Rinaldo Cubeddu, Sanathana Konugolu Venkata Sekar, Srirang Manohar, Antonio Pifferi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b362a617e49d4af7b3400990990e5cb7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b362a617e49d4af7b3400990990e5cb7
record_format	dspace
spelling	oai:doaj.org-article:b362a617e49d4af7b3400990990e5cb72021-12-02T17:04:35ZOptical signatures of radiofrequency ablation in biological tissues10.1038/s41598-021-85653-02045-2322https://doaj.org/article/b362a617e49d4af7b3400990990e5cb72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85653-0https://doaj.org/toc/2045-2322Abstract Accurate monitoring of treatment is crucial in minimally-invasive radiofrequency ablation in oncology and cardiovascular disease. We investigated alterations in optical properties of ex-vivo bovine tissues of the liver, heart, muscle, and brain, undergoing the treatment. Time-domain diffuse optical spectroscopy was used, which enabled us to disentangle and quantify absorption and reduced scattering spectra. In addition to the well-known global (1) decrease in absorption, and (2) increase in reduced scattering, we uncovered new features based on sensitive detection of spectral changes. These absorption spectrum features are: (3) emergence of a peak around 840 nm, (4) redshift of the 760 nm deoxyhemoglobin peak, and (5) blueshift of the 970 nm water peak. Treatment temperatures above 100 °C led to (6) increased absorption at shorter wavelengths, and (7) further decrease in reduced scattering. This optical behavior provides new insights into tissue response to thermal treatment and sets the stage for optical monitoring of radiofrequency ablation.Pranav LankaKalloor Joseph FrancisHindrik KruitAndrea FarinaRinaldo CubedduSanathana Konugolu Venkata SekarSrirang ManoharAntonio PifferiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pranav Lanka Kalloor Joseph Francis Hindrik Kruit Andrea Farina Rinaldo Cubeddu Sanathana Konugolu Venkata Sekar Srirang Manohar Antonio Pifferi Optical signatures of radiofrequency ablation in biological tissues
description	Abstract Accurate monitoring of treatment is crucial in minimally-invasive radiofrequency ablation in oncology and cardiovascular disease. We investigated alterations in optical properties of ex-vivo bovine tissues of the liver, heart, muscle, and brain, undergoing the treatment. Time-domain diffuse optical spectroscopy was used, which enabled us to disentangle and quantify absorption and reduced scattering spectra. In addition to the well-known global (1) decrease in absorption, and (2) increase in reduced scattering, we uncovered new features based on sensitive detection of spectral changes. These absorption spectrum features are: (3) emergence of a peak around 840 nm, (4) redshift of the 760 nm deoxyhemoglobin peak, and (5) blueshift of the 970 nm water peak. Treatment temperatures above 100 °C led to (6) increased absorption at shorter wavelengths, and (7) further decrease in reduced scattering. This optical behavior provides new insights into tissue response to thermal treatment and sets the stage for optical monitoring of radiofrequency ablation.
format	article
author	Pranav Lanka Kalloor Joseph Francis Hindrik Kruit Andrea Farina Rinaldo Cubeddu Sanathana Konugolu Venkata Sekar Srirang Manohar Antonio Pifferi
author_facet	Pranav Lanka Kalloor Joseph Francis Hindrik Kruit Andrea Farina Rinaldo Cubeddu Sanathana Konugolu Venkata Sekar Srirang Manohar Antonio Pifferi
author_sort	Pranav Lanka
title	Optical signatures of radiofrequency ablation in biological tissues
title_short	Optical signatures of radiofrequency ablation in biological tissues
title_full	Optical signatures of radiofrequency ablation in biological tissues
title_fullStr	Optical signatures of radiofrequency ablation in biological tissues
title_full_unstemmed	Optical signatures of radiofrequency ablation in biological tissues
title_sort	optical signatures of radiofrequency ablation in biological tissues
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b362a617e49d4af7b3400990990e5cb7
work_keys_str_mv	AT pranavlanka opticalsignaturesofradiofrequencyablationinbiologicaltissues AT kalloorjosephfrancis opticalsignaturesofradiofrequencyablationinbiologicaltissues AT hindrikkruit opticalsignaturesofradiofrequencyablationinbiologicaltissues AT andreafarina opticalsignaturesofradiofrequencyablationinbiologicaltissues AT rinaldocubeddu opticalsignaturesofradiofrequencyablationinbiologicaltissues AT sanathanakonugoluvenkatasekar opticalsignaturesofradiofrequencyablationinbiologicaltissues AT srirangmanohar opticalsignaturesofradiofrequencyablationinbiologicaltissues AT antoniopifferi opticalsignaturesofradiofrequencyablationinbiologicaltissues
_version_	1718381869367558144

Optical signatures of radiofrequency ablation in biological tissues

Ejemplares similares