Molecular engineering of safe and efficacious oral basal insulin
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/b3637544155945e480839f9c67516402 |
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oai:doaj.org-article:b3637544155945e480839f9c675164022021-12-02T16:31:53ZMolecular engineering of safe and efficacious oral basal insulin10.1038/s41467-020-17487-92041-1723https://doaj.org/article/b3637544155945e480839f9c675164022020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17487-9https://doaj.org/toc/2041-1723Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.Frantisek HubálekHanne H. F. RefsgaardSanne Gram-NielsenPeter MadsenErica NishimuraMartin MünzelChristian Lehn BrandCarsten Enggaard StidsenChristian Hove ClaussenErik Max WulffLone PridalUlla RibelJonas KildegaardTrine PorsgaardEva JohanssonDorte Bjerre SteensgaardLars HovgaardTine GlendorfBo Falck HansenMaja Kirkegaard JensenPeter Kresten NielsenSvend LudvigsenSusanne RughPatrick W. GaribayMary Courtney MooreAlan D. CherringtonThomas KjeldsenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Frantisek Hubálek Hanne H. F. Refsgaard Sanne Gram-Nielsen Peter Madsen Erica Nishimura Martin Münzel Christian Lehn Brand Carsten Enggaard Stidsen Christian Hove Claussen Erik Max Wulff Lone Pridal Ulla Ribel Jonas Kildegaard Trine Porsgaard Eva Johansson Dorte Bjerre Steensgaard Lars Hovgaard Tine Glendorf Bo Falck Hansen Maja Kirkegaard Jensen Peter Kresten Nielsen Svend Ludvigsen Susanne Rugh Patrick W. Garibay Mary Courtney Moore Alan D. Cherrington Thomas Kjeldsen Molecular engineering of safe and efficacious oral basal insulin |
| description |
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues. |
| format |
article |
| author |
Frantisek Hubálek Hanne H. F. Refsgaard Sanne Gram-Nielsen Peter Madsen Erica Nishimura Martin Münzel Christian Lehn Brand Carsten Enggaard Stidsen Christian Hove Claussen Erik Max Wulff Lone Pridal Ulla Ribel Jonas Kildegaard Trine Porsgaard Eva Johansson Dorte Bjerre Steensgaard Lars Hovgaard Tine Glendorf Bo Falck Hansen Maja Kirkegaard Jensen Peter Kresten Nielsen Svend Ludvigsen Susanne Rugh Patrick W. Garibay Mary Courtney Moore Alan D. Cherrington Thomas Kjeldsen |
| author_facet |
Frantisek Hubálek Hanne H. F. Refsgaard Sanne Gram-Nielsen Peter Madsen Erica Nishimura Martin Münzel Christian Lehn Brand Carsten Enggaard Stidsen Christian Hove Claussen Erik Max Wulff Lone Pridal Ulla Ribel Jonas Kildegaard Trine Porsgaard Eva Johansson Dorte Bjerre Steensgaard Lars Hovgaard Tine Glendorf Bo Falck Hansen Maja Kirkegaard Jensen Peter Kresten Nielsen Svend Ludvigsen Susanne Rugh Patrick W. Garibay Mary Courtney Moore Alan D. Cherrington Thomas Kjeldsen |
| author_sort |
Frantisek Hubálek |
| title |
Molecular engineering of safe and efficacious oral basal insulin |
| title_short |
Molecular engineering of safe and efficacious oral basal insulin |
| title_full |
Molecular engineering of safe and efficacious oral basal insulin |
| title_fullStr |
Molecular engineering of safe and efficacious oral basal insulin |
| title_full_unstemmed |
Molecular engineering of safe and efficacious oral basal insulin |
| title_sort |
molecular engineering of safe and efficacious oral basal insulin |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/b3637544155945e480839f9c67516402 |
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