Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly

Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly

Abstract Inner dynein arm (IDA), composed of a series of protein complex, is necessary to cilia and flagella bend formation and beating. Previous studies indicated that defects of IDA protein complex result in multiple morphological abnormalities of the sperm flagellum (MMAF) and male infertility. H...

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Autores principales: Shuai Lu, Yayun Gu, Yifei Wu, Shenmin Yang, Chenmeijie Li, Lanlan Meng, Wenwen Yuan, Tao Jiang, Xin Zhang, Yang Li, Cheng Wang, Mingxi Liu, Lan Ye, Xuejiang Guo, Hongbing Shen, Xiaoyu Yang, Yueqiu Tan, Zhibin Hu
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
Materias:
Cytology
QH573-671
Acceso en línea:https://doaj.org/article/b367dda3089c450db57f37b585da4e7e
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