Synthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment

Biogenic microvesicles (MVs) play a pivotal role in intercellular signal communication, thus initiating critical biological responses such as the proliferation of cancer cells, gene and protein transport, and chemo-drug resistance. In addition, they have been recognized as having great potential in...

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Autores principales:	Wen-Jyun Wang, Chung-Dann Kan, Chih-Yen Chen, Yi-Yao Meng, Jieh-Neng Wang, Wei-Ling Chen, Chia-Hsiang Chen, Wei-Peng Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microvesicles poly(lactic-co-glycolic acid) carbon monoxide emulsion cancer Chemical technology TP1-1185 Chemical engineering TP155-156
Acceso en línea:	https://doaj.org/article/b36910d4b3b64a86af3eebc68cd74f1c
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spelling	oai:doaj.org-article:b36910d4b3b64a86af3eebc68cd74f1c2021-11-25T18:19:34ZSynthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment10.3390/membranes111108182077-0375https://doaj.org/article/b36910d4b3b64a86af3eebc68cd74f1c2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0375/11/11/818https://doaj.org/toc/2077-0375Biogenic microvesicles (MVs) play a pivotal role in intercellular signal communication, thus initiating critical biological responses such as the proliferation of cancer cells, gene and protein transport, and chemo-drug resistance. In addition, they have been recognized as having great potential in drug delivery applications. However, the productivity of biologically produced MVs is not sufficient for clinical applications. In this study, synthetic poly(lactic-co-glycolic acid) (PLGA) MVs were prepared via a double emulsion method. The PLGA MVs had a biogenic MV-mimic vesicular structure with a hydrophilic core/surface and hydrophobic interior of the shell, showing great potential for drug delivery. We successfully embedded hydrophobic iron carbonyl (IC), a carbon monoxide (CO) donor, in the PLGA shell region, enabling the delivery of IC in an aqueous solution. Because of the intrinsic properties of PLGA, it was susceptible to temperature, and the MVs could easily collapse in a warm environment, leading to the decomposition of IC into CO. The in vitro result indicated that the cell viability of A549 lung carcinoma cells significantly decreased to 14% after treatment with IC-loaded PLGA MVs for 24 h, suggesting that these synthetic PLGA MVs constitute an excellent drug delivery platform.Wen-Jyun WangChung-Dann KanChih-Yen ChenYi-Yao MengJieh-Neng WangWei-Ling ChenChia-Hsiang ChenWei-Peng LiMDPI AGarticlemicrovesiclespoly(lactic-co-glycolic acid)carbon monoxideemulsioncancerChemical technologyTP1-1185Chemical engineeringTP155-156ENMembranes, Vol 11, Iss 818, p 818 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microvesicles poly(lactic-co-glycolic acid) carbon monoxide emulsion cancer Chemical technology TP1-1185 Chemical engineering TP155-156
spellingShingle	microvesicles poly(lactic-co-glycolic acid) carbon monoxide emulsion cancer Chemical technology TP1-1185 Chemical engineering TP155-156 Wen-Jyun Wang Chung-Dann Kan Chih-Yen Chen Yi-Yao Meng Jieh-Neng Wang Wei-Ling Chen Chia-Hsiang Chen Wei-Peng Li Synthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment
description	Biogenic microvesicles (MVs) play a pivotal role in intercellular signal communication, thus initiating critical biological responses such as the proliferation of cancer cells, gene and protein transport, and chemo-drug resistance. In addition, they have been recognized as having great potential in drug delivery applications. However, the productivity of biologically produced MVs is not sufficient for clinical applications. In this study, synthetic poly(lactic-co-glycolic acid) (PLGA) MVs were prepared via a double emulsion method. The PLGA MVs had a biogenic MV-mimic vesicular structure with a hydrophilic core/surface and hydrophobic interior of the shell, showing great potential for drug delivery. We successfully embedded hydrophobic iron carbonyl (IC), a carbon monoxide (CO) donor, in the PLGA shell region, enabling the delivery of IC in an aqueous solution. Because of the intrinsic properties of PLGA, it was susceptible to temperature, and the MVs could easily collapse in a warm environment, leading to the decomposition of IC into CO. The in vitro result indicated that the cell viability of A549 lung carcinoma cells significantly decreased to 14% after treatment with IC-loaded PLGA MVs for 24 h, suggesting that these synthetic PLGA MVs constitute an excellent drug delivery platform.
format	article
author	Wen-Jyun Wang Chung-Dann Kan Chih-Yen Chen Yi-Yao Meng Jieh-Neng Wang Wei-Ling Chen Chia-Hsiang Chen Wei-Peng Li
author_facet	Wen-Jyun Wang Chung-Dann Kan Chih-Yen Chen Yi-Yao Meng Jieh-Neng Wang Wei-Ling Chen Chia-Hsiang Chen Wei-Peng Li
author_sort	Wen-Jyun Wang
title	Synthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment
title_short	Synthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment
title_full	Synthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment
title_fullStr	Synthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment
title_full_unstemmed	Synthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment
title_sort	synthetic poly(lactic-co-glycolic acid) microvesicles as a feasible carbon monoxide-releasing platform for cancer treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b36910d4b3b64a86af3eebc68cd74f1c
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Synthetic Poly(lactic-co-glycolic Acid) Microvesicles as a Feasible Carbon Monoxide-Releasing Platform for Cancer Treatment

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