Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART

Background: HIV infection and lifelong cART are responsible of an increase in cardiovascular risk. The aim of this study was to describe the subclinical cardiovascular disease and to identify early markers of cardiovascular damage in adolescents and young adults vertically infected with HIV on cART,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Biagio Castaldi, Gloria Lanzoni, Osvalda Rampon, Daniele Donà, Angela Di Candia, Ornella Milanesi, Carlo Giaquinto, Giovanni Di Salvo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HIV adolescents cardiovascular risk echocardiography early-onset cardiovascular disease Medicine R
Acceso en línea:	https://doaj.org/article/b36971235bc24b5d9ce5468231d3dc82
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b36971235bc24b5d9ce5468231d3dc82
record_format	dspace
spelling	oai:doaj.org-article:b36971235bc24b5d9ce5468231d3dc822021-11-25T18:02:59ZMulti-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART10.3390/jcm102254552077-0383https://doaj.org/article/b36971235bc24b5d9ce5468231d3dc822021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5455https://doaj.org/toc/2077-0383Background: HIV infection and lifelong cART are responsible of an increase in cardiovascular risk. The aim of this study was to describe the subclinical cardiovascular disease and to identify early markers of cardiovascular damage in adolescents and young adults vertically infected with HIV on cART, through an innovative multi-parametric approach. Methods: We enrolled 52 patients vertically infected with HIV. Demographic records, traditional cardiovascular risk factors, laboratory findings and echocardiographic measurements were collected in a one-year routine follow up. The echocardiographic examination included measurements of the 2D and 3D ejection fraction (EF), E/A ratio, E/E′ ratio, carotid intima media thickness (cIMT), flow-mediated dilation (FMD) and global longitudinal strain (GLS). Results: At the time of enrolment, all the patients were on cART therapy. The viral load was suppressed in 95% of them. EF was normal in 94.2% of patients (66 ± 7.2%), and GLS (mean value: −20.0 ± 2.5%) was reduced in 29% of patients. The cIMT mean value was higher than the 95th centile for sex and age in 73%, and FMD was impaired in 45% of patients. Clinically evident disease was found in three patients: dilative cardiomyopathy in one, thoracic-abdominal aneurysm Crawford type II with a bilateral carotid dilation in one and carotid plaque with 30% of stenosis in a third patient. Conclusions: This study confirms the presence of clinical and subclinical cardiovascular disease in a very young population vertically infected with HIV, underlining the importance of an early, multi-parametric cardiovascular follow up.Biagio CastaldiGloria LanzoniOsvalda RamponDaniele DonàAngela Di CandiaOrnella MilanesiCarlo GiaquintoGiovanni Di SalvoMDPI AGarticleHIVadolescentscardiovascular riskechocardiographyearly-onset cardiovascular diseaseMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5455, p 5455 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV adolescents cardiovascular risk echocardiography early-onset cardiovascular disease Medicine R
spellingShingle	HIV adolescents cardiovascular risk echocardiography early-onset cardiovascular disease Medicine R Biagio Castaldi Gloria Lanzoni Osvalda Rampon Daniele Donà Angela Di Candia Ornella Milanesi Carlo Giaquinto Giovanni Di Salvo Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART
description	Background: HIV infection and lifelong cART are responsible of an increase in cardiovascular risk. The aim of this study was to describe the subclinical cardiovascular disease and to identify early markers of cardiovascular damage in adolescents and young adults vertically infected with HIV on cART, through an innovative multi-parametric approach. Methods: We enrolled 52 patients vertically infected with HIV. Demographic records, traditional cardiovascular risk factors, laboratory findings and echocardiographic measurements were collected in a one-year routine follow up. The echocardiographic examination included measurements of the 2D and 3D ejection fraction (EF), E/A ratio, E/E′ ratio, carotid intima media thickness (cIMT), flow-mediated dilation (FMD) and global longitudinal strain (GLS). Results: At the time of enrolment, all the patients were on cART therapy. The viral load was suppressed in 95% of them. EF was normal in 94.2% of patients (66 ± 7.2%), and GLS (mean value: −20.0 ± 2.5%) was reduced in 29% of patients. The cIMT mean value was higher than the 95th centile for sex and age in 73%, and FMD was impaired in 45% of patients. Clinically evident disease was found in three patients: dilative cardiomyopathy in one, thoracic-abdominal aneurysm Crawford type II with a bilateral carotid dilation in one and carotid plaque with 30% of stenosis in a third patient. Conclusions: This study confirms the presence of clinical and subclinical cardiovascular disease in a very young population vertically infected with HIV, underlining the importance of an early, multi-parametric cardiovascular follow up.
format	article
author	Biagio Castaldi Gloria Lanzoni Osvalda Rampon Daniele Donà Angela Di Candia Ornella Milanesi Carlo Giaquinto Giovanni Di Salvo
author_facet	Biagio Castaldi Gloria Lanzoni Osvalda Rampon Daniele Donà Angela Di Candia Ornella Milanesi Carlo Giaquinto Giovanni Di Salvo
author_sort	Biagio Castaldi
title	Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART
title_short	Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART
title_full	Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART
title_fullStr	Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART
title_full_unstemmed	Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART
title_sort	multi-parametric diagnostic approach and potential markers of early onset subclinical cardiovascular disease in a cohort of children, adolescents and young adults vertically infected with hiv on cart
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b36971235bc24b5d9ce5468231d3dc82
work_keys_str_mv	AT biagiocastaldi multiparametricdiagnosticapproachandpotentialmarkersofearlyonsetsubclinicalcardiovasculardiseaseinacohortofchildrenadolescentsandyoungadultsverticallyinfectedwithhivoncart AT glorialanzoni multiparametricdiagnosticapproachandpotentialmarkersofearlyonsetsubclinicalcardiovasculardiseaseinacohortofchildrenadolescentsandyoungadultsverticallyinfectedwithhivoncart AT osvaldarampon multiparametricdiagnosticapproachandpotentialmarkersofearlyonsetsubclinicalcardiovasculardiseaseinacohortofchildrenadolescentsandyoungadultsverticallyinfectedwithhivoncart AT danieledona multiparametricdiagnosticapproachandpotentialmarkersofearlyonsetsubclinicalcardiovasculardiseaseinacohortofchildrenadolescentsandyoungadultsverticallyinfectedwithhivoncart AT angeladicandia multiparametricdiagnosticapproachandpotentialmarkersofearlyonsetsubclinicalcardiovasculardiseaseinacohortofchildrenadolescentsandyoungadultsverticallyinfectedwithhivoncart AT ornellamilanesi multiparametricdiagnosticapproachandpotentialmarkersofearlyonsetsubclinicalcardiovasculardiseaseinacohortofchildrenadolescentsandyoungadultsverticallyinfectedwithhivoncart AT carlogiaquinto multiparametricdiagnosticapproachandpotentialmarkersofearlyonsetsubclinicalcardiovasculardiseaseinacohortofchildrenadolescentsandyoungadultsverticallyinfectedwithhivoncart AT giovannidisalvo multiparametricdiagnosticapproachandpotentialmarkersofearlyonsetsubclinicalcardiovasculardiseaseinacohortofchildrenadolescentsandyoungadultsverticallyinfectedwithhivoncart
_version_	1718411702809133056

Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART

Ejemplares similares