Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer

Abstract This study investigated the relationship between quantitative parameters of shear wave elastography (SWE, maximum elasticity [Emax], minimum elasticity [Emin], mean elasticity [Emean]), collagen intensity and Kindlin-2 expression in benign and malignant breast nodules, and if Kindlin-2 expr...

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Autores principales:	Xiaowei Xue, Junlai Li, Wenbo Wan, Xianquan Shi, Yiqiong Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b36b9edfbe184f8f8852051d201601dd
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spelling	oai:doaj.org-article:b36b9edfbe184f8f8852051d201601dd2021-12-02T12:32:04ZKindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer10.1038/s41598-017-07075-12045-2322https://doaj.org/article/b36b9edfbe184f8f8852051d201601dd2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07075-1https://doaj.org/toc/2045-2322Abstract This study investigated the relationship between quantitative parameters of shear wave elastography (SWE, maximum elasticity [Emax], minimum elasticity [Emin], mean elasticity [Emean]), collagen intensity and Kindlin-2 expression in benign and malignant breast nodules, and if Kindlin-2 expression is related with lymph node metastasis. A total of 102 breast nodules from 102 patients were included in our study who underwent ultrasound elastography before surgery or core needle biopsy. There was a significant difference between benign and malignant breast nodules in Emax, Emean, collagen intensity and Kindlin-2 expression, but it had no difference in Emin. Collagen intensity and Kindlin-2 expression both correlated positively with Emax, but not with Emean. Among 38 malignant breast nodules, the average Emax of the metastasis group was higher than that of the non-metastasis group, but it had no statistical significance. Compared with the non-metastasis group, Kindlin-2 expression was considerably higher in the metastasis group. However, there was no difference in collagen intensity between the metastasis group and the non-metastasis group. In conclusion, Kindlin-2 and collagen might contribute to breast nodule elasticity through molecular mechanisms. In breast cancer, overexpression of Kindlin-2 might be a risk factor for lymph node metastasis.Xiaowei XueJunlai LiWenbo WanXianquan ShiYiqiong ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaowei Xue Junlai Li Wenbo Wan Xianquan Shi Yiqiong Zheng Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer
description	Abstract This study investigated the relationship between quantitative parameters of shear wave elastography (SWE, maximum elasticity [Emax], minimum elasticity [Emin], mean elasticity [Emean]), collagen intensity and Kindlin-2 expression in benign and malignant breast nodules, and if Kindlin-2 expression is related with lymph node metastasis. A total of 102 breast nodules from 102 patients were included in our study who underwent ultrasound elastography before surgery or core needle biopsy. There was a significant difference between benign and malignant breast nodules in Emax, Emean, collagen intensity and Kindlin-2 expression, but it had no difference in Emin. Collagen intensity and Kindlin-2 expression both correlated positively with Emax, but not with Emean. Among 38 malignant breast nodules, the average Emax of the metastasis group was higher than that of the non-metastasis group, but it had no statistical significance. Compared with the non-metastasis group, Kindlin-2 expression was considerably higher in the metastasis group. However, there was no difference in collagen intensity between the metastasis group and the non-metastasis group. In conclusion, Kindlin-2 and collagen might contribute to breast nodule elasticity through molecular mechanisms. In breast cancer, overexpression of Kindlin-2 might be a risk factor for lymph node metastasis.
format	article
author	Xiaowei Xue Junlai Li Wenbo Wan Xianquan Shi Yiqiong Zheng
author_facet	Xiaowei Xue Junlai Li Wenbo Wan Xianquan Shi Yiqiong Zheng
author_sort	Xiaowei Xue
title	Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer
title_short	Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer
title_full	Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer
title_fullStr	Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer
title_full_unstemmed	Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer
title_sort	kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b36b9edfbe184f8f8852051d201601dd
work_keys_str_mv	AT xiaoweixue kindlin2couldinfluencebreastnoduleelasticityandimprovelymphnodemetastasisininvasivebreastcancer AT junlaili kindlin2couldinfluencebreastnoduleelasticityandimprovelymphnodemetastasisininvasivebreastcancer AT wenbowan kindlin2couldinfluencebreastnoduleelasticityandimprovelymphnodemetastasisininvasivebreastcancer AT xianquanshi kindlin2couldinfluencebreastnoduleelasticityandimprovelymphnodemetastasisininvasivebreastcancer AT yiqiongzheng kindlin2couldinfluencebreastnoduleelasticityandimprovelymphnodemetastasisininvasivebreastcancer
_version_	1718394178944106496

Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer

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