Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity

Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity

The differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and that the complex interacts with different lineage spe...

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Autores principales: Joanna Cyrta, Anke Augspach, Maria Rosaria De Filippo, Davide Prandi, Phillip Thienger, Matteo Benelli, Victoria Cooley, Rohan Bareja, David Wilkes, Sung-Suk Chae, Paola Cavaliere, Noah Dephoure, Anne-Christine Uldry, Sophie Braga Lagache, Luca Roma, Sandra Cohen, Muriel Jaquet, Laura P. Brandt, Mohammed Alshalalfa, Loredana Puca, Andrea Sboner, Felix Feng, Shangqian Wang, Himisha Beltran, Tamara Lotan, Martin Spahn, Marianna Kruithof-de Julio, Yu Chen, Karla V. Ballman, Francesca Demichelis, Salvatore Piscuoglio, Mark A. Rubin
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b36e0ab4d6324855a87fa9ba1ed5cc3e
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spelling oai:doaj.org-article:b36e0ab4d6324855a87fa9ba1ed5cc3e2021-12-02T17:32:11ZRole of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity10.1038/s41467-020-19328-12041-1723https://doaj.org/article/b36e0ab4d6324855a87fa9ba1ed5cc3e2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19328-1https://doaj.org/toc/2041-1723The differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and that the complex interacts with different lineage specific factors throughout prostate cancer transdifferentiation.Joanna CyrtaAnke AugspachMaria Rosaria De FilippoDavide PrandiPhillip ThiengerMatteo BenelliVictoria CooleyRohan BarejaDavid WilkesSung-Suk ChaePaola CavaliereNoah DephoureAnne-Christine UldrySophie Braga LagacheLuca RomaSandra CohenMuriel JaquetLaura P. BrandtMohammed AlshalalfaLoredana PucaAndrea SbonerFelix FengShangqian WangHimisha BeltranTamara LotanMartin SpahnMarianna Kruithof-de JulioYu ChenKarla V. BallmanFrancesca DemichelisSalvatore PiscuoglioMark A. RubinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Joanna Cyrta
Anke Augspach
Maria Rosaria De Filippo
Davide Prandi
Phillip Thienger
Matteo Benelli
Victoria Cooley
Rohan Bareja
David Wilkes
Sung-Suk Chae
Paola Cavaliere
Noah Dephoure
Anne-Christine Uldry
Sophie Braga Lagache
Luca Roma
Sandra Cohen
Muriel Jaquet
Laura P. Brandt
Mohammed Alshalalfa
Loredana Puca
Andrea Sboner
Felix Feng
Shangqian Wang
Himisha Beltran
Tamara Lotan
Martin Spahn
Marianna Kruithof-de Julio
Yu Chen
Karla V. Ballman
Francesca Demichelis
Salvatore Piscuoglio
Mark A. Rubin
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
description The differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and that the complex interacts with different lineage specific factors throughout prostate cancer transdifferentiation.
format article
author Joanna Cyrta
Anke Augspach
Maria Rosaria De Filippo
Davide Prandi
Phillip Thienger
Matteo Benelli
Victoria Cooley
Rohan Bareja
David Wilkes
Sung-Suk Chae
Paola Cavaliere
Noah Dephoure
Anne-Christine Uldry
Sophie Braga Lagache
Luca Roma
Sandra Cohen
Muriel Jaquet
Laura P. Brandt
Mohammed Alshalalfa
Loredana Puca
Andrea Sboner
Felix Feng
Shangqian Wang
Himisha Beltran
Tamara Lotan
Martin Spahn
Marianna Kruithof-de Julio
Yu Chen
Karla V. Ballman
Francesca Demichelis
Salvatore Piscuoglio
Mark A. Rubin
author_facet Joanna Cyrta
Anke Augspach
Maria Rosaria De Filippo
Davide Prandi
Phillip Thienger
Matteo Benelli
Victoria Cooley
Rohan Bareja
David Wilkes
Sung-Suk Chae
Paola Cavaliere
Noah Dephoure
Anne-Christine Uldry
Sophie Braga Lagache
Luca Roma
Sandra Cohen
Muriel Jaquet
Laura P. Brandt
Mohammed Alshalalfa
Loredana Puca
Andrea Sboner
Felix Feng
Shangqian Wang
Himisha Beltran
Tamara Lotan
Martin Spahn
Marianna Kruithof-de Julio
Yu Chen
Karla V. Ballman
Francesca Demichelis
Salvatore Piscuoglio
Mark A. Rubin
author_sort Joanna Cyrta
title Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_short Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_full Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_fullStr Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_full_unstemmed Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_sort role of specialized composition of swi/snf complexes in prostate cancer lineage plasticity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b36e0ab4d6324855a87fa9ba1ed5cc3e
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