Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment

In this study, novel nanostructures of aluminum base metal-organic framework (Al-MOF) samples were synthesized using a sustainable, non-toxic, and cost-effective green synthesis route. Satureja hortensis extract was used as an effective source of linker for the development of the Al-MOF structures....

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Autores principales:	Malihe Zeraati, Abbas Rahdar, Dora I. Medina, Ghasem Sargazi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	novel Al-MOF green synthesis S. hortensis extract caffeic acid ligand anticancer properties Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b36e1d383751475f943e95427550afd8
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spelling	oai:doaj.org-article:b36e1d383751475f943e95427550afd82021-12-01T18:01:13ZSynthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment2296-264610.3389/fchem.2021.784461https://doaj.org/article/b36e1d383751475f943e95427550afd82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.784461/fullhttps://doaj.org/toc/2296-2646In this study, novel nanostructures of aluminum base metal-organic framework (Al-MOF) samples were synthesized using a sustainable, non-toxic, and cost-effective green synthesis route. Satureja hortensis extract was used as an effective source of linker for the development of the Al-MOF structures. The Fourier-transformed infrared (FTIR) spectrum confirmed the presence of characterization bonds related to the Al-MOF nanostructures synthesized by the green synthesis route. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses revealed that the sample synthesized by Na2-CA was composed of multilayers, although it was agglomerated, but it had dispersed and occurred in spherical particles, indicating active organic matter. N2 adsorption/desorption isotherms demonstrated the significant porosity of the Al-MOF samples that facilitate the high potential of these nanostructures in medical applications. The anticancer treatment of Al-MOF samples was performed with different concentrations using the MTT standard method with untreated cancer cells for 24 and 48 h periods. The results exhibited the significant anticancer properties of Al-MOF samples developed in this study when compared with other MOF samples. Thus, the development of a novel Al-MOF and its application as a natural linker can influence the anticancer treatment of the samples. According to the results, the products developed in this study can be used in more applications such as biosensors, catalysts, and novel adsorbents.Malihe ZeraatiAbbas RahdarDora I. MedinaGhasem SargaziFrontiers Media S.A.articlenovel Al-MOFgreen synthesisS. hortensis extractcaffeic acid ligandanticancer propertiesChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	novel Al-MOF green synthesis S. hortensis extract caffeic acid ligand anticancer properties Chemistry QD1-999
spellingShingle	novel Al-MOF green synthesis S. hortensis extract caffeic acid ligand anticancer properties Chemistry QD1-999 Malihe Zeraati Abbas Rahdar Dora I. Medina Ghasem Sargazi Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment
description	In this study, novel nanostructures of aluminum base metal-organic framework (Al-MOF) samples were synthesized using a sustainable, non-toxic, and cost-effective green synthesis route. Satureja hortensis extract was used as an effective source of linker for the development of the Al-MOF structures. The Fourier-transformed infrared (FTIR) spectrum confirmed the presence of characterization bonds related to the Al-MOF nanostructures synthesized by the green synthesis route. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses revealed that the sample synthesized by Na2-CA was composed of multilayers, although it was agglomerated, but it had dispersed and occurred in spherical particles, indicating active organic matter. N2 adsorption/desorption isotherms demonstrated the significant porosity of the Al-MOF samples that facilitate the high potential of these nanostructures in medical applications. The anticancer treatment of Al-MOF samples was performed with different concentrations using the MTT standard method with untreated cancer cells for 24 and 48 h periods. The results exhibited the significant anticancer properties of Al-MOF samples developed in this study when compared with other MOF samples. Thus, the development of a novel Al-MOF and its application as a natural linker can influence the anticancer treatment of the samples. According to the results, the products developed in this study can be used in more applications such as biosensors, catalysts, and novel adsorbents.
format	article
author	Malihe Zeraati Abbas Rahdar Dora I. Medina Ghasem Sargazi
author_facet	Malihe Zeraati Abbas Rahdar Dora I. Medina Ghasem Sargazi
author_sort	Malihe Zeraati
title	Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment
title_short	Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment
title_full	Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment
title_fullStr	Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment
title_full_unstemmed	Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment
title_sort	synthesis of al-based metal-organic framework in water with caffeic acid ligand and naoh as linker sources with highly efficient anticancer treatment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b36e1d383751475f943e95427550afd8
work_keys_str_mv	AT malihezeraati synthesisofalbasedmetalorganicframeworkinwaterwithcaffeicacidligandandnaohaslinkersourceswithhighlyefficientanticancertreatment AT abbasrahdar synthesisofalbasedmetalorganicframeworkinwaterwithcaffeicacidligandandnaohaslinkersourceswithhighlyefficientanticancertreatment AT doraimedina synthesisofalbasedmetalorganicframeworkinwaterwithcaffeicacidligandandnaohaslinkersourceswithhighlyefficientanticancertreatment AT ghasemsargazi synthesisofalbasedmetalorganicframeworkinwaterwithcaffeicacidligandandnaohaslinkersourceswithhighlyefficientanticancertreatment
_version_	1718404771179659264

Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment

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