Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Aleksandra Wlodek, Steve G. Kendrew, Nigel J. Coates, Adam Hold, Joanna Pogwizd, Steven Rudder, Lesley S. Sheehan, Sarah J. Higginbotham, Anna E. Stanley-Smith, Tony Warneck, Mohammad Nur-E-Alam, Markus Radzom, Christine J. Martin, Lois Overvoorde, Markiyan Samborskyy, Silke Alt, Daniel Heine, Guy T. Carter, Edmund I. Graziani, Frank E. Koehn, Leonard McDonald, Alexander Alanine, Rosa María Rodríguez Sarmiento, Suzan Keen Chao, Hasane Ratni, Lucinda Steward, Isobel H. Norville, Mitali Sarkar-Tyson, Steven J. Moss, Peter F. Leadlay, Barrie Wilkinson, Matthew A. Gregory
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/b36ef21246ab47bfb8cbd4e969caea7c
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/b36ef21246ab47bfb8cbd4e969caea7c

Documents similaires