Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody response in pre-pandemic cohorts and assess heteroty...

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Autores principales:	Kevin J. Selva, Carolien E. van de Sandt, Melissa M. Lemke, Christina Y. Lee, Suzanne K. Shoffner, Brendon Y. Chua, Samantha K. Davis, Thi H. O. Nguyen, Louise C. Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C. Jackson, Katie L. Flanagan, Jane Crowe, Shidan Tosif, Melanie R. Neeland, Philip Sutton, Paul V. Licciardi, Nigel W. Crawford, Allen C. Cheng, Denise L. Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran, Daniel Watterson, Paul Young, Wen Shi Lee, Bruce D. Wines, P. Mark Hogarth, Robyn Esterbauer, Hannah G. Kelly, Hyon-Xhi Tan, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Kelly B. Arnold, Katherine Kedzierska, Amy W. Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3735969bc2442d3bede1a835ba02866
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spelling	oai:doaj.org-article:b3735969bc2442d3bede1a835ba028662021-12-02T18:17:38ZSystems serology detects functionally distinct coronavirus antibody features in children and elderly10.1038/s41467-021-22236-72041-1723https://doaj.org/article/b3735969bc2442d3bede1a835ba028662021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22236-7https://doaj.org/toc/2041-1723Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody response in pre-pandemic cohorts and assess heterotypic reactivity to SARS-CoV-2.Kevin J. SelvaCarolien E. van de SandtMelissa M. LemkeChristina Y. LeeSuzanne K. ShoffnerBrendon Y. ChuaSamantha K. DavisThi H. O. NguyenLouise C. RowntreeLuca HensenMarios KoutsakosChinn Yi WongFrancesca MordantDavid C. JacksonKatie L. FlanaganJane CroweShidan TosifMelanie R. NeelandPhilip SuttonPaul V. LicciardiNigel W. CrawfordAllen C. ChengDenise L. DoolanFatima AmanatFlorian KrammerKeith ChappellNaphak ModhiranDaniel WattersonPaul YoungWen Shi LeeBruce D. WinesP. Mark HogarthRobyn EsterbauerHannah G. KellyHyon-Xhi TanJennifer A. JunoAdam K. WheatleyStephen J. KentKelly B. ArnoldKatherine KedzierskaAmy W. ChungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin J. Selva Carolien E. van de Sandt Melissa M. Lemke Christina Y. Lee Suzanne K. Shoffner Brendon Y. Chua Samantha K. Davis Thi H. O. Nguyen Louise C. Rowntree Luca Hensen Marios Koutsakos Chinn Yi Wong Francesca Mordant David C. Jackson Katie L. Flanagan Jane Crowe Shidan Tosif Melanie R. Neeland Philip Sutton Paul V. Licciardi Nigel W. Crawford Allen C. Cheng Denise L. Doolan Fatima Amanat Florian Krammer Keith Chappell Naphak Modhiran Daniel Watterson Paul Young Wen Shi Lee Bruce D. Wines P. Mark Hogarth Robyn Esterbauer Hannah G. Kelly Hyon-Xhi Tan Jennifer A. Juno Adam K. Wheatley Stephen J. Kent Kelly B. Arnold Katherine Kedzierska Amy W. Chung Systems serology detects functionally distinct coronavirus antibody features in children and elderly
description	Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody response in pre-pandemic cohorts and assess heterotypic reactivity to SARS-CoV-2.
format	article
author	Kevin J. Selva Carolien E. van de Sandt Melissa M. Lemke Christina Y. Lee Suzanne K. Shoffner Brendon Y. Chua Samantha K. Davis Thi H. O. Nguyen Louise C. Rowntree Luca Hensen Marios Koutsakos Chinn Yi Wong Francesca Mordant David C. Jackson Katie L. Flanagan Jane Crowe Shidan Tosif Melanie R. Neeland Philip Sutton Paul V. Licciardi Nigel W. Crawford Allen C. Cheng Denise L. Doolan Fatima Amanat Florian Krammer Keith Chappell Naphak Modhiran Daniel Watterson Paul Young Wen Shi Lee Bruce D. Wines P. Mark Hogarth Robyn Esterbauer Hannah G. Kelly Hyon-Xhi Tan Jennifer A. Juno Adam K. Wheatley Stephen J. Kent Kelly B. Arnold Katherine Kedzierska Amy W. Chung
author_facet	Kevin J. Selva Carolien E. van de Sandt Melissa M. Lemke Christina Y. Lee Suzanne K. Shoffner Brendon Y. Chua Samantha K. Davis Thi H. O. Nguyen Louise C. Rowntree Luca Hensen Marios Koutsakos Chinn Yi Wong Francesca Mordant David C. Jackson Katie L. Flanagan Jane Crowe Shidan Tosif Melanie R. Neeland Philip Sutton Paul V. Licciardi Nigel W. Crawford Allen C. Cheng Denise L. Doolan Fatima Amanat Florian Krammer Keith Chappell Naphak Modhiran Daniel Watterson Paul Young Wen Shi Lee Bruce D. Wines P. Mark Hogarth Robyn Esterbauer Hannah G. Kelly Hyon-Xhi Tan Jennifer A. Juno Adam K. Wheatley Stephen J. Kent Kelly B. Arnold Katherine Kedzierska Amy W. Chung
author_sort	Kevin J. Selva
title	Systems serology detects functionally distinct coronavirus antibody features in children and elderly
title_short	Systems serology detects functionally distinct coronavirus antibody features in children and elderly
title_full	Systems serology detects functionally distinct coronavirus antibody features in children and elderly
title_fullStr	Systems serology detects functionally distinct coronavirus antibody features in children and elderly
title_full_unstemmed	Systems serology detects functionally distinct coronavirus antibody features in children and elderly
title_sort	systems serology detects functionally distinct coronavirus antibody features in children and elderly
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3735969bc2442d3bede1a835ba02866
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Systems serology detects functionally distinct coronavirus antibody features in children and elderly

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