Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?

The shape and spatial organization -the anatomy- of a tissue profoundly influences its function. Knowledge of the anatomical relationships between parent and daughter cells is necessary to understand differentiation and how the crosstalk between the different cells in the tissue leads to physiologic...

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Autores principales:	Qingqing Wu, Jizhou Zhang, Daniel Lucas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anatomy of the bone marrow spatial organization of hematopoiesis microenvironment niches dynamics of hematopoiesis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b3746d1441e641debf3a418a78c587cd
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spelling	oai:doaj.org-article:b3746d1441e641debf3a418a78c587cd2021-11-11T07:35:48ZAnatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?1664-322410.3389/fimmu.2021.768439https://doaj.org/article/b3746d1441e641debf3a418a78c587cd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.768439/fullhttps://doaj.org/toc/1664-3224The shape and spatial organization -the anatomy- of a tissue profoundly influences its function. Knowledge of the anatomical relationships between parent and daughter cells is necessary to understand differentiation and how the crosstalk between the different cells in the tissue leads to physiological maintenance and pathological perturbations. Blood cell production takes place in the bone marrow through the progressive differentiation of stem cells and progenitors. These are maintained and regulated by a heterogeneous microenvironment composed of stromal and hematopoietic cells. While hematopoiesis has been studied in extraordinary detail through functional and multiomics approaches, much less is known about the spatial organization of blood production and how local cues from the microenvironment influence this anatomy. Here, we discuss some of the studies that revealed a complex anatomy of hematopoiesis where discrete local microenvironments spatially organize and regulate specific subsets of hematopoietic stem cells and/or progenitors. We focus on the open questions in the field and discuss how new tools and technological advances are poised to transform our understanding of the anatomy of hematopoiesis.Qingqing WuJizhou ZhangDaniel LucasDaniel LucasFrontiers Media S.A.articleanatomy of the bone marrowspatial organization of hematopoiesismicroenvironmentnichesdynamics of hematopoiesisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anatomy of the bone marrow spatial organization of hematopoiesis microenvironment niches dynamics of hematopoiesis Immunologic diseases. Allergy RC581-607
spellingShingle	anatomy of the bone marrow spatial organization of hematopoiesis microenvironment niches dynamics of hematopoiesis Immunologic diseases. Allergy RC581-607 Qingqing Wu Jizhou Zhang Daniel Lucas Daniel Lucas Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?
description	The shape and spatial organization -the anatomy- of a tissue profoundly influences its function. Knowledge of the anatomical relationships between parent and daughter cells is necessary to understand differentiation and how the crosstalk between the different cells in the tissue leads to physiological maintenance and pathological perturbations. Blood cell production takes place in the bone marrow through the progressive differentiation of stem cells and progenitors. These are maintained and regulated by a heterogeneous microenvironment composed of stromal and hematopoietic cells. While hematopoiesis has been studied in extraordinary detail through functional and multiomics approaches, much less is known about the spatial organization of blood production and how local cues from the microenvironment influence this anatomy. Here, we discuss some of the studies that revealed a complex anatomy of hematopoiesis where discrete local microenvironments spatially organize and regulate specific subsets of hematopoietic stem cells and/or progenitors. We focus on the open questions in the field and discuss how new tools and technological advances are poised to transform our understanding of the anatomy of hematopoiesis.
format	article
author	Qingqing Wu Jizhou Zhang Daniel Lucas Daniel Lucas
author_facet	Qingqing Wu Jizhou Zhang Daniel Lucas Daniel Lucas
author_sort	Qingqing Wu
title	Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?
title_short	Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?
title_full	Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?
title_fullStr	Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?
title_full_unstemmed	Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?
title_sort	anatomy of hematopoiesis and local microenvironments in the bone marrow. where to?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b3746d1441e641debf3a418a78c587cd
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Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?

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