The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific

Abstract Vitamin D deficiency is increasing around the world and has been associated with the development of asthma. This study aims to evaluate the effect of dietary vitamin D deficiency at different life stages on lung function using a murine model of allergic airways disease. BALB/c mice were cha...

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Autores principales:	Nailê K. Nuñez, Ellen Bennett, Ling Chen, Paulo Márcio Pitrez, Graeme R. Zosky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b374d7ebdddc4e06b07c12cf3574c7c9
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spelling	oai:doaj.org-article:b374d7ebdddc4e06b07c12cf3574c7c92021-12-02T11:52:15ZThe independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific10.1038/s41598-017-15517-z2045-2322https://doaj.org/article/b374d7ebdddc4e06b07c12cf3574c7c92017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-15517-zhttps://doaj.org/toc/2045-2322Abstract Vitamin D deficiency is increasing around the world and has been associated with the development of asthma. This study aims to evaluate the effect of dietary vitamin D deficiency at different life stages on lung function using a murine model of allergic airways disease. BALB/c mice were challenged intranasally with HDM or saline alone for 10 days. Twenty four hours after the last challenge, mice were anesthetized and lung function was measured using the forced oscillation technique (FOT). Mice were euthanized for assessment of inflammation in the bronchoalveolar lavage (BAL) and total collagen content in lung homogenates by ELISA. Vitamin D deficiency impaired lung function in both male and female mice, increasing tissue damping and elastance, however had no effect on HDM induced inflammation. The impact of vitamin D deficiency was more evident in females. HDM also decreased airway distensibility, but only in females and this response was not altered by vitamin D deficiency. Our data suggest that vitamin D deficiency and HDM exposure have independent effects on lung mechanics and that females are more susceptible to these effects. Vitamin D deficiency may exacerbate lung function deficits by having a direct, but independent, effect on parenchymal mechanics.Nailê K. NuñezEllen BennettLing ChenPaulo Márcio PitrezGraeme R. ZoskyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nailê K. Nuñez Ellen Bennett Ling Chen Paulo Márcio Pitrez Graeme R. Zosky The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific
description	Abstract Vitamin D deficiency is increasing around the world and has been associated with the development of asthma. This study aims to evaluate the effect of dietary vitamin D deficiency at different life stages on lung function using a murine model of allergic airways disease. BALB/c mice were challenged intranasally with HDM or saline alone for 10 days. Twenty four hours after the last challenge, mice were anesthetized and lung function was measured using the forced oscillation technique (FOT). Mice were euthanized for assessment of inflammation in the bronchoalveolar lavage (BAL) and total collagen content in lung homogenates by ELISA. Vitamin D deficiency impaired lung function in both male and female mice, increasing tissue damping and elastance, however had no effect on HDM induced inflammation. The impact of vitamin D deficiency was more evident in females. HDM also decreased airway distensibility, but only in females and this response was not altered by vitamin D deficiency. Our data suggest that vitamin D deficiency and HDM exposure have independent effects on lung mechanics and that females are more susceptible to these effects. Vitamin D deficiency may exacerbate lung function deficits by having a direct, but independent, effect on parenchymal mechanics.
format	article
author	Nailê K. Nuñez Ellen Bennett Ling Chen Paulo Márcio Pitrez Graeme R. Zosky
author_facet	Nailê K. Nuñez Ellen Bennett Ling Chen Paulo Márcio Pitrez Graeme R. Zosky
author_sort	Nailê K. Nuñez
title	The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific
title_short	The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific
title_full	The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific
title_fullStr	The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific
title_full_unstemmed	The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific
title_sort	independent effects of vitamin d deficiency and house dust mite exposure on lung function are sex-specific
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b374d7ebdddc4e06b07c12cf3574c7c9
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The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific

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