Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases

As the primary component of elastic fibers, elastin plays an important role in maintaining the elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and organs. Studies have shown that elastin expression is regulated by a variety of molecules that have positive and negat...

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Autores principales:	Keke Wang, Xiangguang Meng, Zhikun Guo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	elastin matrix metalloproteinase myocardial ischemia-reperfusion atherosclerosis atrial fibrillation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b37b11b411e34e7e9def51e89e6e0f7a
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spelling	oai:doaj.org-article:b37b11b411e34e7e9def51e89e6e0f7a2021-12-01T19:40:53ZElastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases2296-634X10.3389/fcell.2021.596702https://doaj.org/article/b37b11b411e34e7e9def51e89e6e0f7a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.596702/fullhttps://doaj.org/toc/2296-634XAs the primary component of elastic fibers, elastin plays an important role in maintaining the elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and organs. Studies have shown that elastin expression is regulated by a variety of molecules that have positive and negative regulatory effects. However, the specific mechanism is unclear. Moreover, elastin is reportedly involved in the development and progression of many cardiovascular diseases through changes in its expression and structural modifications once deposited in the extracellular matrix. This review article summarizes the role of elastin in myocardial ischemia-reperfusion, atherosclerosis, and atrial fibrillation, with emphasis on the potential molecular regulatory mechanisms.Keke WangXiangguang MengZhikun GuoZhikun GuoFrontiers Media S.A.articleelastinmatrix metalloproteinasemyocardial ischemia-reperfusionatherosclerosisatrial fibrillationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	elastin matrix metalloproteinase myocardial ischemia-reperfusion atherosclerosis atrial fibrillation Biology (General) QH301-705.5
spellingShingle	elastin matrix metalloproteinase myocardial ischemia-reperfusion atherosclerosis atrial fibrillation Biology (General) QH301-705.5 Keke Wang Xiangguang Meng Zhikun Guo Zhikun Guo Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases
description	As the primary component of elastic fibers, elastin plays an important role in maintaining the elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and organs. Studies have shown that elastin expression is regulated by a variety of molecules that have positive and negative regulatory effects. However, the specific mechanism is unclear. Moreover, elastin is reportedly involved in the development and progression of many cardiovascular diseases through changes in its expression and structural modifications once deposited in the extracellular matrix. This review article summarizes the role of elastin in myocardial ischemia-reperfusion, atherosclerosis, and atrial fibrillation, with emphasis on the potential molecular regulatory mechanisms.
format	article
author	Keke Wang Xiangguang Meng Zhikun Guo Zhikun Guo
author_facet	Keke Wang Xiangguang Meng Zhikun Guo Zhikun Guo
author_sort	Keke Wang
title	Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases
title_short	Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases
title_full	Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases
title_fullStr	Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases
title_full_unstemmed	Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases
title_sort	elastin structure, synthesis, regulatory mechanism and relationship with cardiovascular diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b37b11b411e34e7e9def51e89e6e0f7a
work_keys_str_mv	AT kekewang elastinstructuresynthesisregulatorymechanismandrelationshipwithcardiovasculardiseases AT xiangguangmeng elastinstructuresynthesisregulatorymechanismandrelationshipwithcardiovasculardiseases AT zhikunguo elastinstructuresynthesisregulatorymechanismandrelationshipwithcardiovasculardiseases AT zhikunguo elastinstructuresynthesisregulatorymechanismandrelationshipwithcardiovasculardiseases
_version_	1718404651317985280

Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases

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