Effects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles

Abstract Conventional core-shell polymer nanoparticles usually exhibit a rapid release rate with their release kinetics mainly adjusted through changing composition of the polymer shells, limiting their applications for prolonged drug delivery. As a solution to these problems, silica xerogel/polymer...

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Autores principales:	Wenfei Huang, Chi Pong Tsui, Chak Yin Tang, Linxia Gu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b37b7687b4674037824e6e9ba572bd64
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spelling	oai:doaj.org-article:b37b7687b4674037824e6e9ba572bd642021-12-02T15:07:46ZEffects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles10.1038/s41598-018-31070-92045-2322https://doaj.org/article/b37b7687b4674037824e6e9ba572bd642018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31070-9https://doaj.org/toc/2045-2322Abstract Conventional core-shell polymer nanoparticles usually exhibit a rapid release rate with their release kinetics mainly adjusted through changing composition of the polymer shells, limiting their applications for prolonged drug delivery. As a solution to these problems, silica xerogel/polymer core-shell-structured composite nanoparticles have been proposed. Different with our previous work centring on studying process variables, we here focused on investigating the effects of key compositional variables on essential properties of the composite nanoparticles. The drug release profiles (in vitro) were well interpreted by the Baker and Lonsdale model on a predicted two-stage basis. The first stage (<1 day) was well controlled from 18.6% to 45.9%; the second stage (1–14 days) was tailored in a range from 28.7 to 58.2% by changing the composition of the silica xerogel cores and polymeric shells. A substantial achievement was reducing the release rate by more than 40 times compared with that of conventional polymer nanoparticles by virtue of the silica xerogel cores. A semi-empirical model was also established in the first attempt to describe the effects of polymer concentration and drug loading capacity on the size of the composite nanoparticles. All these results indicated that the composite nanoparticles are promising candidates for prolonged drug delivery applications.Wenfei HuangChi Pong TsuiChak Yin TangLinxia GuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wenfei Huang Chi Pong Tsui Chak Yin Tang Linxia Gu Effects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles
description	Abstract Conventional core-shell polymer nanoparticles usually exhibit a rapid release rate with their release kinetics mainly adjusted through changing composition of the polymer shells, limiting their applications for prolonged drug delivery. As a solution to these problems, silica xerogel/polymer core-shell-structured composite nanoparticles have been proposed. Different with our previous work centring on studying process variables, we here focused on investigating the effects of key compositional variables on essential properties of the composite nanoparticles. The drug release profiles (in vitro) were well interpreted by the Baker and Lonsdale model on a predicted two-stage basis. The first stage (<1 day) was well controlled from 18.6% to 45.9%; the second stage (1–14 days) was tailored in a range from 28.7 to 58.2% by changing the composition of the silica xerogel cores and polymeric shells. A substantial achievement was reducing the release rate by more than 40 times compared with that of conventional polymer nanoparticles by virtue of the silica xerogel cores. A semi-empirical model was also established in the first attempt to describe the effects of polymer concentration and drug loading capacity on the size of the composite nanoparticles. All these results indicated that the composite nanoparticles are promising candidates for prolonged drug delivery applications.
format	article
author	Wenfei Huang Chi Pong Tsui Chak Yin Tang Linxia Gu
author_facet	Wenfei Huang Chi Pong Tsui Chak Yin Tang Linxia Gu
author_sort	Wenfei Huang
title	Effects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles
title_short	Effects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles
title_full	Effects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles
title_fullStr	Effects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles
title_full_unstemmed	Effects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles
title_sort	effects of compositional tailoring on drug delivery behaviours of silica xerogel/polymer core-shell composite nanoparticles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b37b7687b4674037824e6e9ba572bd64
work_keys_str_mv	AT wenfeihuang effectsofcompositionaltailoringondrugdeliverybehavioursofsilicaxerogelpolymercoreshellcompositenanoparticles AT chipongtsui effectsofcompositionaltailoringondrugdeliverybehavioursofsilicaxerogelpolymercoreshellcompositenanoparticles AT chakyintang effectsofcompositionaltailoringondrugdeliverybehavioursofsilicaxerogelpolymercoreshellcompositenanoparticles AT linxiagu effectsofcompositionaltailoringondrugdeliverybehavioursofsilicaxerogelpolymercoreshellcompositenanoparticles
_version_	1718388411149058048

Effects of Compositional Tailoring on Drug Delivery Behaviours of Silica Xerogel/Polymer Core-shell Composite Nanoparticles

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