Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study

Laura A Conrad,1 Natalie Buchinsky,2 Luis M Acosta,2 J David Nugent,3 Khalil W Savary,4 Rachel L Miller,5 Nurdant Emanet,6 Julie Herbstman,2 Beatrice Beebe,6 Michael M Myers,3 William P Fifer,3 Matthew S Perzanowski2 1Division of Respiratory and Sleep Medicine, Albert Einstein College of Medicine, N...

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Autores principales:	Conrad LA, Buchinsky N, Acosta LM, Nugent JD, Savary KW, Miller RL, Emanet N, Herbstman J, Beebe B, Myers MM, Fifer WP, Perzanowski MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	watery eyes still-face challenge rhinitis exercise-induced asthma autonomic nervous system heart rate variability Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b37c92fd84c64a6592a47c0bc12532d9
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spelling	oai:doaj.org-article:b37c92fd84c64a6592a47c0bc12532d92021-11-09T18:40:35ZIncreased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study1178-6965https://doaj.org/article/b37c92fd84c64a6592a47c0bc12532d92021-11-01T00:00:00Zhttps://www.dovepress.com/increased-heart-rate-variability-response-among-infants-with-reported--peer-reviewed-fulltext-article-JAAhttps://doaj.org/toc/1178-6965Laura A Conrad,1 Natalie Buchinsky,2 Luis M Acosta,2 J David Nugent,3 Khalil W Savary,4 Rachel L Miller,5 Nurdant Emanet,6 Julie Herbstman,2 Beatrice Beebe,6 Michael M Myers,3 William P Fifer,3 Matthew S Perzanowski2 1Division of Respiratory and Sleep Medicine, Albert Einstein College of Medicine, New York, NY, USA; 2Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA; 3Division of Developmental Neuroscience, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA; 4Department of Pediatrics, Rutgers University, Newark, NJ, USA; 5Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 6Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USACorrespondence: Matthew S PerzanowskiDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 West 168th St, 11th Floor, New York, NY, 10032, USATel +1 212-305-3465Fax +1 212-305-4012Email mp2217@cumc.columbia.eduIntroduction: Previously, we found that reported infant rhinorrhea and watery eyes without a cold (RWWC) predicted school age exercise-induced wheeze, emergency department visits, and hospitalizations. These findings were independent of allergic sensitization, and we theorized that increased parasympathetic tone underlay the association. We also reported that increased heart-rate variability (HRV) in infants predicted wheeze in 2– 3 year-olds. In a convenience sample of children participating in a birth cohort study, we tested the hypothesis that infants with RWWC would have elevated HRV, indicating increased parasympathetic tone.Methods: RWWC symptoms since birth were queried for 3-month-old children. At 4-months, HRV was assessed (root mean square of successive differences [RMSSD]) during a standardized infant–mother still-face paradigm, which included 2 minutes of mother/child play immediately followed by 2 minutes of the mother maintaining a still-face.Results: Among participants (n=38), RWWC was common for girls (32%) and boys (21%). The children with the greatest decrease in RMSSD between play and still-face challenge (lowest tertile) had a higher prevalence of RWWC as compared with children in the higher tertiles (50% vs 16%, P=0.045). In a logistic regression model controlling for sex, age and time between HRV and RWWC assessment, children with greater decrease in HRV between play and still-face (lowest tertile) had greater odds of having RWWC (odds ratio=6.0, P=0.029).Conclusion: In this relatively small study, we demonstrated greater decreases in HRV in response to a stressor among children with reported RWWC, suggesting that these children might have increased parasympathetic tone and/or overall greater vagal reactivity.Keywords: watery eyes, still-face challenge, rhinitis, exercise-induced asthma, autonomic nervous system, heart rate variabilityConrad LABuchinsky NAcosta LMNugent JDSavary KWMiller RLEmanet NHerbstman JBeebe BMyers MMFifer WPPerzanowski MSDove Medical Pressarticlewatery eyesstill-face challengerhinitisexercise-induced asthmaautonomic nervous systemheart rate variabilityImmunologic diseases. AllergyRC581-607ENJournal of Asthma and Allergy, Vol Volume 14, Pp 1349-1354 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	watery eyes still-face challenge rhinitis exercise-induced asthma autonomic nervous system heart rate variability Immunologic diseases. Allergy RC581-607
spellingShingle	watery eyes still-face challenge rhinitis exercise-induced asthma autonomic nervous system heart rate variability Immunologic diseases. Allergy RC581-607 Conrad LA Buchinsky N Acosta LM Nugent JD Savary KW Miller RL Emanet N Herbstman J Beebe B Myers MM Fifer WP Perzanowski MS Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study
description	Laura A Conrad,1 Natalie Buchinsky,2 Luis M Acosta,2 J David Nugent,3 Khalil W Savary,4 Rachel L Miller,5 Nurdant Emanet,6 Julie Herbstman,2 Beatrice Beebe,6 Michael M Myers,3 William P Fifer,3 Matthew S Perzanowski2 1Division of Respiratory and Sleep Medicine, Albert Einstein College of Medicine, New York, NY, USA; 2Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA; 3Division of Developmental Neuroscience, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA; 4Department of Pediatrics, Rutgers University, Newark, NJ, USA; 5Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 6Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USACorrespondence: Matthew S PerzanowskiDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 West 168th St, 11th Floor, New York, NY, 10032, USATel +1 212-305-3465Fax +1 212-305-4012Email mp2217@cumc.columbia.eduIntroduction: Previously, we found that reported infant rhinorrhea and watery eyes without a cold (RWWC) predicted school age exercise-induced wheeze, emergency department visits, and hospitalizations. These findings were independent of allergic sensitization, and we theorized that increased parasympathetic tone underlay the association. We also reported that increased heart-rate variability (HRV) in infants predicted wheeze in 2– 3 year-olds. In a convenience sample of children participating in a birth cohort study, we tested the hypothesis that infants with RWWC would have elevated HRV, indicating increased parasympathetic tone.Methods: RWWC symptoms since birth were queried for 3-month-old children. At 4-months, HRV was assessed (root mean square of successive differences [RMSSD]) during a standardized infant–mother still-face paradigm, which included 2 minutes of mother/child play immediately followed by 2 minutes of the mother maintaining a still-face.Results: Among participants (n=38), RWWC was common for girls (32%) and boys (21%). The children with the greatest decrease in RMSSD between play and still-face challenge (lowest tertile) had a higher prevalence of RWWC as compared with children in the higher tertiles (50% vs 16%, P=0.045). In a logistic regression model controlling for sex, age and time between HRV and RWWC assessment, children with greater decrease in HRV between play and still-face (lowest tertile) had greater odds of having RWWC (odds ratio=6.0, P=0.029).Conclusion: In this relatively small study, we demonstrated greater decreases in HRV in response to a stressor among children with reported RWWC, suggesting that these children might have increased parasympathetic tone and/or overall greater vagal reactivity.Keywords: watery eyes, still-face challenge, rhinitis, exercise-induced asthma, autonomic nervous system, heart rate variability
format	article
author	Conrad LA Buchinsky N Acosta LM Nugent JD Savary KW Miller RL Emanet N Herbstman J Beebe B Myers MM Fifer WP Perzanowski MS
author_facet	Conrad LA Buchinsky N Acosta LM Nugent JD Savary KW Miller RL Emanet N Herbstman J Beebe B Myers MM Fifer WP Perzanowski MS
author_sort	Conrad LA
title	Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study
title_short	Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study
title_full	Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study
title_fullStr	Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study
title_full_unstemmed	Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study
title_sort	increased heart rate variability response among infants with reported rhinorrhea and watery eyes: a pilot study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b37c92fd84c64a6592a47c0bc12532d9
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Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study

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