Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices

Agnès Ferroni,1 Florian Gaudin,1 Gérard Guiffant,2 Patrice Flaud,2 Jean-Jacques Durussel,2 Philippe Descamps,1 Patrick Berche,1 Xavier Nassif,1 Jacques Merckx2 1Assistance Publique-Hôpitaux de Paris, Laboratory of Microbiology, University Teaching Hospital Necker-Enf...

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Autores principales:	Ferroni A, Gaudin F, Guiffant G, Flaud P, Durussel JJ, Descamps P, Berche P, Nassif X, Merckx J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/b37f6ec34c3245c59eaf8a059d945380
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spelling	oai:doaj.org-article:b37f6ec34c3245c59eaf8a059d9453802021-12-02T02:56:43ZPulsative flushing as a strategy to prevent bacterial colonization of vascular access devices1179-1470https://doaj.org/article/b37f6ec34c3245c59eaf8a059d9453802014-11-01T00:00:00Zhttp://www.dovepress.com/pulsative-flushing-as-a-strategy-to-prevent-bacterial-colonization-of--peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470 Agnès Ferroni,1 Florian Gaudin,1 Gérard Guiffant,2 Patrice Flaud,2 Jean-Jacques Durussel,2 Philippe Descamps,1 Patrick Berche,1 Xavier Nassif,1 Jacques Merckx2 1Assistance Publique-Hôpitaux de Paris, Laboratory of Microbiology, University Teaching Hospital Necker-Enfants Malades, 2University Paris-Diderot, MSC-UMR, CNRS 7057, Paris, France Abstract: Central venous device infections are associated with increased physical and psychological morbidity, mortality, length of stay, and costs. The aim of this study was to prove the efficacy of pulsatile flushing to prevent the bacterial colonization of vascular access devices. One hundred and forty four tests using 576 polyurethane short venous access catheters were performed. Four catheters per test were polluted with a fibronectin-serum albumin solution. Three were filled with a Staphylococcus aureus broth; one served as negative control. One contaminated catheter was not flushed (positive control), and two were flushed (10 mL.sec-1) with normal saline solution, either by ten successive boluses of 1 mL each or by one bolus of 10 mL. Each catheter was cultivated. The S. aureus quantity observed after continuous flushing was significantly higher than that observed after pulsative flushing (P<0.001). Unflushed catheters were 20.71 and 6.42 times more polluted than catheters flushed with the pulsative method or the continuous method, respectively. Pulsative flushing was at least twice as effective as continuous flushing in reducing the S. aureus count. Pulsative flushing is more effective than continuous flushing in reducing the endoluminal contamination. Pulsative flushing is a simple, effective, and inexpensive technique to reduce catheter bacterial colonization.Keywords: peripheral or central venous devices, hydrodynamics, bacterial colonization prevention, pulsative flushing Ferroni AGaudin FGuiffant GFlaud PDurussel JJDescamps PBerche PNassif XMerckx JDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2014, Iss default, Pp 379-383 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Ferroni A Gaudin F Guiffant G Flaud P Durussel JJ Descamps P Berche P Nassif X Merckx J Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices
description	Agnès Ferroni,1 Florian Gaudin,1 Gérard Guiffant,2 Patrice Flaud,2 Jean-Jacques Durussel,2 Philippe Descamps,1 Patrick Berche,1 Xavier Nassif,1 Jacques Merckx2 1Assistance Publique-Hôpitaux de Paris, Laboratory of Microbiology, University Teaching Hospital Necker-Enfants Malades, 2University Paris-Diderot, MSC-UMR, CNRS 7057, Paris, France Abstract: Central venous device infections are associated with increased physical and psychological morbidity, mortality, length of stay, and costs. The aim of this study was to prove the efficacy of pulsatile flushing to prevent the bacterial colonization of vascular access devices. One hundred and forty four tests using 576 polyurethane short venous access catheters were performed. Four catheters per test were polluted with a fibronectin-serum albumin solution. Three were filled with a Staphylococcus aureus broth; one served as negative control. One contaminated catheter was not flushed (positive control), and two were flushed (10 mL.sec-1) with normal saline solution, either by ten successive boluses of 1 mL each or by one bolus of 10 mL. Each catheter was cultivated. The S. aureus quantity observed after continuous flushing was significantly higher than that observed after pulsative flushing (P<0.001). Unflushed catheters were 20.71 and 6.42 times more polluted than catheters flushed with the pulsative method or the continuous method, respectively. Pulsative flushing was at least twice as effective as continuous flushing in reducing the S. aureus count. Pulsative flushing is more effective than continuous flushing in reducing the endoluminal contamination. Pulsative flushing is a simple, effective, and inexpensive technique to reduce catheter bacterial colonization.Keywords: peripheral or central venous devices, hydrodynamics, bacterial colonization prevention, pulsative flushing
format	article
author	Ferroni A Gaudin F Guiffant G Flaud P Durussel JJ Descamps P Berche P Nassif X Merckx J
author_facet	Ferroni A Gaudin F Guiffant G Flaud P Durussel JJ Descamps P Berche P Nassif X Merckx J
author_sort	Ferroni A
title	Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices
title_short	Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices
title_full	Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices
title_fullStr	Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices
title_full_unstemmed	Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices
title_sort	pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b37f6ec34c3245c59eaf8a059d945380
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Pulsative flushing as a strategy to prevent bacterial colonization of vascular access devices

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