Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application

Wei Song1, Xiaowei Yu2, Sunxi Wang5, Ralph Blasier4, David C Markel3, Guangzhao Mao5, Tong Shi1, Weiping Ren1,31Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA; 2Department of Orthopedic Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing, People...

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Autores principales:	Song W, Yu X, Wang S, Blasier R, Markel DC, Mao G, Shi T, Ren W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b38120e6451b4e81b4adf8b7faa1af73
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spelling	oai:doaj.org-article:b38120e6451b4e81b4adf8b7faa1af732021-12-02T02:43:33ZCyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application1176-91141178-2013https://doaj.org/article/b38120e6451b4e81b4adf8b7faa1af732011-12-01T00:00:00Zhttp://www.dovepress.com/cyclodextrin-erythromycin-complexes-as-a-drug-delivery-device-for-orth-a8825https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Wei Song1, Xiaowei Yu2, Sunxi Wang5, Ralph Blasier4, David C Markel3, Guangzhao Mao5, Tong Shi1, Weiping Ren1,31Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA; 2Department of Orthopedic Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing, People&#39;s Republic of China; 3Detroit Medical Center and Providence Hospital Orthopedic Residency, Detroit, 4Orthopedic Section, St Francis Hospital, Escanaba, 5Department of Chemical Engineering, Wayne State University, Detroit, MI, USABackground: Erythromycin, a hydrophobic antibiotic used to treat infectious diseases, is now gaining attention because of its anti-inflammatory effects and ability to inhibit osteoclasts formation. The aim of this study was to explore a cyclodextrin-erythromycin (CD-EM) complex for sustained treatment of orthopedic inflammation.Methods and results: Erythromycin was reacted with &szlig;-cyclodextrin to form a nonhost-guest CD-EM complex using both kneading and stirring approaches. Physiochemical measurement data indicated that erythromycin and cyclodextrin formed a packing complex driven by intermolecular forces instead of a host-guest structure due to the limited space in the inner cavity of &szlig;-cyclodextrin. The CD-EM complex improved the stability of erythromycin in aqueous solution and had a longer duration of bactericidal activity than free erythromycin. Cytotoxicity and cell differentiation were evaluated in both murine MC3T3 preosteoblast cells and RAW 264.7 murine macrophage cells. The CD-EM complex was noncytotoxic and showed significant inhibition of osteoclast formation but had little effect on osteoblast viability and differentiation.Conclusion: These attributes are especially important for the delivery of an adequate amount of erythromycin to the site of periprosthetic inflammation and reducing local inflammation in a sustained manner.Keywords: erythromycin, cyclodextrin, drug stability, bactericidal activity, osteoclastogenesisSong WYu XWang SBlasier RMarkel DCMao GShi TRen WDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 3173-3186 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Song W Yu X Wang S Blasier R Markel DC Mao G Shi T Ren W Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application
description	Wei Song1, Xiaowei Yu2, Sunxi Wang5, Ralph Blasier4, David C Markel3, Guangzhao Mao5, Tong Shi1, Weiping Ren1,31Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA; 2Department of Orthopedic Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing, People&#39;s Republic of China; 3Detroit Medical Center and Providence Hospital Orthopedic Residency, Detroit, 4Orthopedic Section, St Francis Hospital, Escanaba, 5Department of Chemical Engineering, Wayne State University, Detroit, MI, USABackground: Erythromycin, a hydrophobic antibiotic used to treat infectious diseases, is now gaining attention because of its anti-inflammatory effects and ability to inhibit osteoclasts formation. The aim of this study was to explore a cyclodextrin-erythromycin (CD-EM) complex for sustained treatment of orthopedic inflammation.Methods and results: Erythromycin was reacted with &szlig;-cyclodextrin to form a nonhost-guest CD-EM complex using both kneading and stirring approaches. Physiochemical measurement data indicated that erythromycin and cyclodextrin formed a packing complex driven by intermolecular forces instead of a host-guest structure due to the limited space in the inner cavity of &szlig;-cyclodextrin. The CD-EM complex improved the stability of erythromycin in aqueous solution and had a longer duration of bactericidal activity than free erythromycin. Cytotoxicity and cell differentiation were evaluated in both murine MC3T3 preosteoblast cells and RAW 264.7 murine macrophage cells. The CD-EM complex was noncytotoxic and showed significant inhibition of osteoclast formation but had little effect on osteoblast viability and differentiation.Conclusion: These attributes are especially important for the delivery of an adequate amount of erythromycin to the site of periprosthetic inflammation and reducing local inflammation in a sustained manner.Keywords: erythromycin, cyclodextrin, drug stability, bactericidal activity, osteoclastogenesis
format	article
author	Song W Yu X Wang S Blasier R Markel DC Mao G Shi T Ren W
author_facet	Song W Yu X Wang S Blasier R Markel DC Mao G Shi T Ren W
author_sort	Song W
title	Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application
title_short	Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application
title_full	Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application
title_fullStr	Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application
title_full_unstemmed	Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application
title_sort	cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/b38120e6451b4e81b4adf8b7faa1af73
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Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application

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