Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)

Katayama et al. report a vibrational spectroscopic study using ATR–FTIR of the human M2 muscarinic acetylcholine receptor (M2R). Their work involves an extensive comparison of agonists, antagonists, and inverse agonists, in which they show that they C = O stretching amide–I band is correlated with t...

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Autores principales:	Kota Katayama, Kohei Suzuki, Ryoji Suno, Ryoji Kise, Hirokazu Tsujimoto, So Iwata, Asuka Inoue, Takuya Kobayashi, Hideki Kandori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b3828602dcf7414d9c2ba883ffb0d5f1
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spelling	oai:doaj.org-article:b3828602dcf7414d9c2ba883ffb0d5f12021-11-28T12:10:21ZVibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)10.1038/s42003-021-02836-12399-3642https://doaj.org/article/b3828602dcf7414d9c2ba883ffb0d5f12021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02836-1https://doaj.org/toc/2399-3642Katayama et al. report a vibrational spectroscopic study using ATR–FTIR of the human M2 muscarinic acetylcholine receptor (M2R). Their work involves an extensive comparison of agonists, antagonists, and inverse agonists, in which they show that they C = O stretching amide–I band is correlated with the ligand binding efficiency.Kota KatayamaKohei SuzukiRyoji SunoRyoji KiseHirokazu TsujimotoSo IwataAsuka InoueTakuya KobayashiHideki KandoriNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kota Katayama Kohei Suzuki Ryoji Suno Ryoji Kise Hirokazu Tsujimoto So Iwata Asuka Inoue Takuya Kobayashi Hideki Kandori Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)
description	Katayama et al. report a vibrational spectroscopic study using ATR–FTIR of the human M2 muscarinic acetylcholine receptor (M2R). Their work involves an extensive comparison of agonists, antagonists, and inverse agonists, in which they show that they C = O stretching amide–I band is correlated with the ligand binding efficiency.
format	article
author	Kota Katayama Kohei Suzuki Ryoji Suno Ryoji Kise Hirokazu Tsujimoto So Iwata Asuka Inoue Takuya Kobayashi Hideki Kandori
author_facet	Kota Katayama Kohei Suzuki Ryoji Suno Ryoji Kise Hirokazu Tsujimoto So Iwata Asuka Inoue Takuya Kobayashi Hideki Kandori
author_sort	Kota Katayama
title	Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)
title_short	Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)
title_full	Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)
title_fullStr	Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)
title_full_unstemmed	Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)
title_sort	vibrational spectroscopy analysis of ligand efficacy in human m2 muscarinic acetylcholine receptor (m2r)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3828602dcf7414d9c2ba883ffb0d5f1
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Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)

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