EFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS

Objective: To study the gross morphology of skeletal muscles and plasma Creatinine phosphokinase levels of rats and find effect of long acting β2-agonists co-administration in Statin induced myopathies. Study Design: Quasi experimental study. Place and Duration of Study: Department of Anatomy,...

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Autores principales:	Abdullah Qamar, Hina Kundi, Maria Yousaf, Sajid Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	creatine phosphokinase formoterol myopathy skeletal muscle Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b3851bafeec848d8b44885f53844fe89
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spelling	oai:doaj.org-article:b3851bafeec848d8b44885f53844fe892021-11-10T02:41:00ZEFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS0030-96482411-8842https://doaj.org/article/b3851bafeec848d8b44885f53844fe892019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3415/2390https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To study the gross morphology of skeletal muscles and plasma Creatinine phosphokinase levels of rats and find effect of long acting β2-agonists co-administration in Statin induced myopathies. Study Design: Quasi experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad and Armed forces institute of Pathology (AFIP) Rawalpindi, from Jan 2015 to Jun 2016. Methodology: Adult male Sprague-Dawley rats were procured from NIH Islamabad. Their average approximate age was 70-80 days with weight range 250 ± 50 grams. The animals were randomly selected and divided into three groups. Group A was the control. Each rat of group B received Simvastatin dissolved in distilled water, by oral gavage (60mg/kg/day) once daily, for 12 weeks. Animals of Group C received simvastatin dissolved in distilled water, (60mg/kg/day) once daily plus for dissolved in distilled water (3μg/kg/day) once daily for 12 weeks. 5ml sample of blood was taken in a plain tube directly from the heart for the quantitative measurement of creatine phosphokinase (CPK) levels before sacrificing of the animals. The animals were sacrificed after three months of the experimental period. Results: Examination of plasma levels of CPK of the control group revealed the normal values. It was significantly higher in group B as compared to the control group A. The serum creatine phosphokinase levels showed a decrease in the mean levels after treatment with Formoterol in group C Conclusion: Simvastatin induced the myopathic changes in the skeletal muscle of experimental rats which was shown by increased CPK levels. Formoterol co-administration decreased CPK levels in simvastatin induced myopathies.Abdullah QamarHina KundiMaria YousafSajid AliArmy Medical College Rawalpindiarticlecreatine phosphokinaseformoterolmyopathyskeletal muscleMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 1065-1070 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	creatine phosphokinase formoterol myopathy skeletal muscle Medicine R Medicine (General) R5-920
spellingShingle	creatine phosphokinase formoterol myopathy skeletal muscle Medicine R Medicine (General) R5-920 Abdullah Qamar Hina Kundi Maria Yousaf Sajid Ali EFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS
description	Objective: To study the gross morphology of skeletal muscles and plasma Creatinine phosphokinase levels of rats and find effect of long acting β2-agonists co-administration in Statin induced myopathies. Study Design: Quasi experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad and Armed forces institute of Pathology (AFIP) Rawalpindi, from Jan 2015 to Jun 2016. Methodology: Adult male Sprague-Dawley rats were procured from NIH Islamabad. Their average approximate age was 70-80 days with weight range 250 ± 50 grams. The animals were randomly selected and divided into three groups. Group A was the control. Each rat of group B received Simvastatin dissolved in distilled water, by oral gavage (60mg/kg/day) once daily, for 12 weeks. Animals of Group C received simvastatin dissolved in distilled water, (60mg/kg/day) once daily plus for dissolved in distilled water (3μg/kg/day) once daily for 12 weeks. 5ml sample of blood was taken in a plain tube directly from the heart for the quantitative measurement of creatine phosphokinase (CPK) levels before sacrificing of the animals. The animals were sacrificed after three months of the experimental period. Results: Examination of plasma levels of CPK of the control group revealed the normal values. It was significantly higher in group B as compared to the control group A. The serum creatine phosphokinase levels showed a decrease in the mean levels after treatment with Formoterol in group C Conclusion: Simvastatin induced the myopathic changes in the skeletal muscle of experimental rats which was shown by increased CPK levels. Formoterol co-administration decreased CPK levels in simvastatin induced myopathies.
format	article
author	Abdullah Qamar Hina Kundi Maria Yousaf Sajid Ali
author_facet	Abdullah Qamar Hina Kundi Maria Yousaf Sajid Ali
author_sort	Abdullah Qamar
title	EFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS
title_short	EFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS
title_full	EFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS
title_fullStr	EFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS
title_full_unstemmed	EFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS
title_sort	effect of long acting β2-agonists on gross morphology of skeletal muscles and creatine phosphokinase level in simvastatin induced myopathies in rats
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/b3851bafeec848d8b44885f53844fe89
work_keys_str_mv	AT abdullahqamar effectoflongactingb2agonistsongrossmorphologyofskeletalmusclesandcreatinephosphokinaselevelinsimvastatininducedmyopathiesinrats AT hinakundi effectoflongactingb2agonistsongrossmorphologyofskeletalmusclesandcreatinephosphokinaselevelinsimvastatininducedmyopathiesinrats AT mariayousaf effectoflongactingb2agonistsongrossmorphologyofskeletalmusclesandcreatinephosphokinaselevelinsimvastatininducedmyopathiesinrats AT sajidali effectoflongactingb2agonistsongrossmorphologyofskeletalmusclesandcreatinephosphokinaselevelinsimvastatininducedmyopathiesinrats
_version_	1718440778074685440

EFFECT OF LONG ACTING β2-AGONISTS ON GROSS MORPHOLOGY OF SKELETAL MUSCLES AND CREATINE PHOSPHOKINASE LEVEL IN SIMVASTATIN INDUCED MYOPATHIES IN RATS

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