Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes

LACC1 genetic variants are associated with Crohn's disease, leprosy and arthritis. Here the authors show that LACC1 is needed for optimal innate receptor-induced signalling, mitochondrial ROS production and microbial clearance, effects that are reduced by a Crohn's disease-risk variant in...

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Autores principales:	Amit Lahiri, Matija Hedl, Jie Yan, Clara Abraham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3899d585b3a48d7aef42d5a79383ca3
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spelling	oai:doaj.org-article:b3899d585b3a48d7aef42d5a79383ca32021-12-02T14:42:26ZHuman LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes10.1038/ncomms156142041-1723https://doaj.org/article/b3899d585b3a48d7aef42d5a79383ca32017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15614https://doaj.org/toc/2041-1723LACC1 genetic variants are associated with Crohn's disease, leprosy and arthritis. Here the authors show that LACC1 is needed for optimal innate receptor-induced signalling, mitochondrial ROS production and microbial clearance, effects that are reduced by a Crohn's disease-risk variant in LACC1.Amit LahiriMatija HedlJie YanClara AbrahamNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amit Lahiri Matija Hedl Jie Yan Clara Abraham Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
description	LACC1 genetic variants are associated with Crohn's disease, leprosy and arthritis. Here the authors show that LACC1 is needed for optimal innate receptor-induced signalling, mitochondrial ROS production and microbial clearance, effects that are reduced by a Crohn's disease-risk variant in LACC1.
format	article
author	Amit Lahiri Matija Hedl Jie Yan Clara Abraham
author_facet	Amit Lahiri Matija Hedl Jie Yan Clara Abraham
author_sort	Amit Lahiri
title	Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
title_short	Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
title_full	Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
title_fullStr	Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
title_full_unstemmed	Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
title_sort	human lacc1 increases innate receptor-induced responses and a lacc1 disease-risk variant modulates these outcomes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b3899d585b3a48d7aef42d5a79383ca3
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Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes

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