Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees

Abstract The adipokinetic hormone (AKH) of insects is considered an equivalent of the mammalian hormone glucagon as it induces fast mobilization of carbohydrates and lipids from the fat body upon starvation. Yet, in foraging honey bees, which lack fat body storage for carbohydrates, it was suggested...

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Autores principales:	Gabriela de Brito Sanchez, Anna Expósito Muñoz, Li Chen, Weifone Huang, Songkun Su, Martin Giurfa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b38d3711e13c45c8959b03a71d71bc59
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spelling	oai:doaj.org-article:b38d3711e13c45c8959b03a71d71bc592021-12-02T15:16:05ZAdipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees10.1038/s41598-021-97851-x2045-2322https://doaj.org/article/b38d3711e13c45c8959b03a71d71bc592021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97851-xhttps://doaj.org/toc/2045-2322Abstract The adipokinetic hormone (AKH) of insects is considered an equivalent of the mammalian hormone glucagon as it induces fast mobilization of carbohydrates and lipids from the fat body upon starvation. Yet, in foraging honey bees, which lack fat body storage for carbohydrates, it was suggested that AKH may have lost its original function. Here we manipulated the energy budget of bee foragers to determine the effect of AKH on appetitive responses. As AKH participates in a cascade leading to acceptance of unpalatable substances in starved Drosophila, we also assessed its effect on foragers presented with sucrose solution spiked with salicin. Starved and partially-fed bees were topically exposed with different doses of AKH to determine if this hormone modifies food ingestion and sucrose responsiveness. We found a significant effect of the energy budget (i.e. starved vs. partially-fed) on the decision to ingest or respond to both pure sucrose solution and sucrose solution spiked with salicin, but no effect of AKH per se. These results are consistent with a loss of function of AKH in honey bee foragers, in accordance with a social life that implies storing energy resources in the hive, in amounts that exceed individual needs.Gabriela de Brito SanchezAnna Expósito MuñozLi ChenWeifone HuangSongkun SuMartin GiurfaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gabriela de Brito Sanchez Anna Expósito Muñoz Li Chen Weifone Huang Songkun Su Martin Giurfa Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees
description	Abstract The adipokinetic hormone (AKH) of insects is considered an equivalent of the mammalian hormone glucagon as it induces fast mobilization of carbohydrates and lipids from the fat body upon starvation. Yet, in foraging honey bees, which lack fat body storage for carbohydrates, it was suggested that AKH may have lost its original function. Here we manipulated the energy budget of bee foragers to determine the effect of AKH on appetitive responses. As AKH participates in a cascade leading to acceptance of unpalatable substances in starved Drosophila, we also assessed its effect on foragers presented with sucrose solution spiked with salicin. Starved and partially-fed bees were topically exposed with different doses of AKH to determine if this hormone modifies food ingestion and sucrose responsiveness. We found a significant effect of the energy budget (i.e. starved vs. partially-fed) on the decision to ingest or respond to both pure sucrose solution and sucrose solution spiked with salicin, but no effect of AKH per se. These results are consistent with a loss of function of AKH in honey bee foragers, in accordance with a social life that implies storing energy resources in the hive, in amounts that exceed individual needs.
format	article
author	Gabriela de Brito Sanchez Anna Expósito Muñoz Li Chen Weifone Huang Songkun Su Martin Giurfa
author_facet	Gabriela de Brito Sanchez Anna Expósito Muñoz Li Chen Weifone Huang Songkun Su Martin Giurfa
author_sort	Gabriela de Brito Sanchez
title	Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees
title_short	Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees
title_full	Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees
title_fullStr	Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees
title_full_unstemmed	Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees
title_sort	adipokinetic hormone (akh), energy budget and their effect on feeding and gustatory processes of foraging honey bees
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b38d3711e13c45c8959b03a71d71bc59
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Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees

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