ADAR1-mediated regulation of melanoma invasion

In metastatic melanoma, ADAR1 is downregulated, facilitating proliferation. Here, the authors show an ADAR1-dependent and RNA-editing-independent regulation of melanoma invasion mediated by ITGB3 expression, which can be reversed when ITGB3 is blocked.

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Autores principales:	Yael Nemlich, Erez Nissim Baruch, Michal Judith Besser, Einav Shoshan, Menashe Bar-Eli, Liat Anafi, Iris Barshack, Jacob Schachter, Rona Ortenberg, Gal Markel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3931c919fb84915ae92ef05fa08880c
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spelling	oai:doaj.org-article:b3931c919fb84915ae92ef05fa08880c2021-12-02T17:32:32ZADAR1-mediated regulation of melanoma invasion10.1038/s41467-018-04600-22041-1723https://doaj.org/article/b3931c919fb84915ae92ef05fa08880c2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04600-2https://doaj.org/toc/2041-1723In metastatic melanoma, ADAR1 is downregulated, facilitating proliferation. Here, the authors show an ADAR1-dependent and RNA-editing-independent regulation of melanoma invasion mediated by ITGB3 expression, which can be reversed when ITGB3 is blocked.Yael NemlichErez Nissim BaruchMichal Judith BesserEinav ShoshanMenashe Bar-EliLiat AnafiIris BarshackJacob SchachterRona OrtenbergGal MarkelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yael Nemlich Erez Nissim Baruch Michal Judith Besser Einav Shoshan Menashe Bar-Eli Liat Anafi Iris Barshack Jacob Schachter Rona Ortenberg Gal Markel ADAR1-mediated regulation of melanoma invasion
description	In metastatic melanoma, ADAR1 is downregulated, facilitating proliferation. Here, the authors show an ADAR1-dependent and RNA-editing-independent regulation of melanoma invasion mediated by ITGB3 expression, which can be reversed when ITGB3 is blocked.
format	article
author	Yael Nemlich Erez Nissim Baruch Michal Judith Besser Einav Shoshan Menashe Bar-Eli Liat Anafi Iris Barshack Jacob Schachter Rona Ortenberg Gal Markel
author_facet	Yael Nemlich Erez Nissim Baruch Michal Judith Besser Einav Shoshan Menashe Bar-Eli Liat Anafi Iris Barshack Jacob Schachter Rona Ortenberg Gal Markel
author_sort	Yael Nemlich
title	ADAR1-mediated regulation of melanoma invasion
title_short	ADAR1-mediated regulation of melanoma invasion
title_full	ADAR1-mediated regulation of melanoma invasion
title_fullStr	ADAR1-mediated regulation of melanoma invasion
title_full_unstemmed	ADAR1-mediated regulation of melanoma invasion
title_sort	adar1-mediated regulation of melanoma invasion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b3931c919fb84915ae92ef05fa08880c
work_keys_str_mv	AT yaelnemlich adar1mediatedregulationofmelanomainvasion AT ereznissimbaruch adar1mediatedregulationofmelanomainvasion AT michaljudithbesser adar1mediatedregulationofmelanomainvasion AT einavshoshan adar1mediatedregulationofmelanomainvasion AT menashebareli adar1mediatedregulationofmelanomainvasion AT liatanafi adar1mediatedregulationofmelanomainvasion AT irisbarshack adar1mediatedregulationofmelanomainvasion AT jacobschachter adar1mediatedregulationofmelanomainvasion AT ronaortenberg adar1mediatedregulationofmelanomainvasion AT galmarkel adar1mediatedregulationofmelanomainvasion
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ADAR1-mediated regulation of melanoma invasion

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