ADAR1-mediated regulation of melanoma invasion
In metastatic melanoma, ADAR1 is downregulated, facilitating proliferation. Here, the authors show an ADAR1-dependent and RNA-editing-independent regulation of melanoma invasion mediated by ITGB3 expression, which can be reversed when ITGB3 is blocked.
Saved in:
Main Authors: | Yael Nemlich, Erez Nissim Baruch, Michal Judith Besser, Einav Shoshan, Menashe Bar-Eli, Liat Anafi, Iris Barshack, Jacob Schachter, Rona Ortenberg, Gal Markel |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
|
Subjects: | |
Online Access: | https://doaj.org/article/b3931c919fb84915ae92ef05fa08880c |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Regulation of cancer aggressive features in melanoma cells by microRNAs.
by: Eyal Greenberg, et al.
Published: (2011) -
The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
by: Gal Markel, et al.
Published: (2010) -
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
by: Guermarie Velazquez-Torres, et al.
Published: (2018) -
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
by: Hugh S. Gannon, et al.
Published: (2018) -
Deciphering the Biological Significance of ADAR1–Z-RNA Interactions
by: Taisuke Nakahama, et al.
Published: (2021)