An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes

Aberrant NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation in innate immune cells, triggered by diverse cellular danger signals, leads to the production of inflammatory cytokines (IL-1β and IL-18) and cell death by pyroptosis. These processes are involved in the patho...

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Autores principales:	Aroa Baragaño Raneros, Cristian Ruiz Bernet, Aida Bernardo Flórez, Beatriz Suarez-Alvarez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NLRP3 epigenetics inflammasome IL-1β pyroptosis acetylation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b393e03cce004486bd1a1371d6c2716b
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spelling	oai:doaj.org-article:b393e03cce004486bd1a1371d6c2716b2021-11-25T16:49:37ZAn Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes10.3390/biomedicines91116142227-9059https://doaj.org/article/b393e03cce004486bd1a1371d6c2716b2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1614https://doaj.org/toc/2227-9059Aberrant NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation in innate immune cells, triggered by diverse cellular danger signals, leads to the production of inflammatory cytokines (IL-1β and IL-18) and cell death by pyroptosis. These processes are involved in the pathogenesis of a wide range of diseases such as autoimmune, neurodegenerative, renal, metabolic, vascular diseases and cancer, and during physiological processes such as aging. Epigenetic dynamics mediated by changes in DNA methylation patterns, chromatin assembly and non-coding RNA expression are key regulators of the expression of inflammasome components and its further activation. Here, we review the role of the epigenome in the expression, assembly, and activation of the NLRP3 inflammasome, providing a critical overview of its involvement in the disease and discussing how targeting these mechanisms by epigenetic treatments could be a useful strategy for controlling NLRP3-related inflammatory diseases.Aroa Baragaño RanerosCristian Ruiz BernetAida Bernardo FlórezBeatriz Suarez-AlvarezMDPI AGarticleNLRP3epigeneticsinflammasomeIL-1βpyroptosisacetylationBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1614, p 1614 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NLRP3 epigenetics inflammasome IL-1β pyroptosis acetylation Biology (General) QH301-705.5
spellingShingle	NLRP3 epigenetics inflammasome IL-1β pyroptosis acetylation Biology (General) QH301-705.5 Aroa Baragaño Raneros Cristian Ruiz Bernet Aida Bernardo Flórez Beatriz Suarez-Alvarez An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes
description	Aberrant NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation in innate immune cells, triggered by diverse cellular danger signals, leads to the production of inflammatory cytokines (IL-1β and IL-18) and cell death by pyroptosis. These processes are involved in the pathogenesis of a wide range of diseases such as autoimmune, neurodegenerative, renal, metabolic, vascular diseases and cancer, and during physiological processes such as aging. Epigenetic dynamics mediated by changes in DNA methylation patterns, chromatin assembly and non-coding RNA expression are key regulators of the expression of inflammasome components and its further activation. Here, we review the role of the epigenome in the expression, assembly, and activation of the NLRP3 inflammasome, providing a critical overview of its involvement in the disease and discussing how targeting these mechanisms by epigenetic treatments could be a useful strategy for controlling NLRP3-related inflammatory diseases.
format	article
author	Aroa Baragaño Raneros Cristian Ruiz Bernet Aida Bernardo Flórez Beatriz Suarez-Alvarez
author_facet	Aroa Baragaño Raneros Cristian Ruiz Bernet Aida Bernardo Flórez Beatriz Suarez-Alvarez
author_sort	Aroa Baragaño Raneros
title	An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes
title_short	An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes
title_full	An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes
title_fullStr	An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes
title_full_unstemmed	An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes
title_sort	epigenetic insight into nlrp3 inflammasome activation in inflammation-related processes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b393e03cce004486bd1a1371d6c2716b
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An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes

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