Role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period
We studied the composition of phospholipids and phospholipase A2 in 96 pregnant women c cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus 1 : 1600). It was found that the aggravation of CMV infection in pregnant women is accompanied with membrane-destructive phenomena, which are...
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Scientific Сentre for Family Health and Human Reproduction Problems
2015
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oai:doaj.org-article:b39744e694c341bdadc8bac65fc618f72021-11-23T06:14:32ZRole of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period2541-94202587-9596https://doaj.org/article/b39744e694c341bdadc8bac65fc618f72015-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/71https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596We studied the composition of phospholipids and phospholipase A2 in 96 pregnant women c cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus 1 : 1600). It was found that the aggravation of CMV infection in pregnant women is accompanied with membrane-destructive phenomena, which are based on the activation of phospholipase A2 and the modification of the phospholipid matrix exhibits decrease of phosphatidylethanolamine (I trimester - by 24%, II trimester - by 16 %, III trimester - by 9 % (p < 0,001)); phosphatidylcholine (I trimester - by 14 %, II trimester - by 16 %, III trimester - 23 % (p < 0,001)); phosphatidylserine (I trimester - by 46 % (p < 0,001), II trimester - by 33 % (p < 0,01), III trimester - by 101 % (p < 0,001)). Increasing the concentration of sphingomyelin (I trimester - by 16 %, II and III trimesters - by 9 %; p < 0,001), lysophosphatidylcholine (I trimester - by 71 %, II trimester - 59 %, III trimester - by 51 % (p < 0,001)) compared with healthy women. Identified changes may be the significant factor in violation of the deformability of cells, red blood cell hemolysis, increased microviscosity blood, and therefore is the cause of fetal hypoxia.N. A. IshutinaScientific Сentre for Family Health and Human Reproduction Problemsarticlephospholipidsphospholipase a<sub>2</sub>pregnancycytomegalovirus infectionScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3, Pp 52-55 (2015) |
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phospholipids phospholipase a<sub>2</sub> pregnancy cytomegalovirus infection Science Q |
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phospholipids phospholipase a<sub>2</sub> pregnancy cytomegalovirus infection Science Q N. A. Ishutina Role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period |
| description |
We studied the composition of phospholipids and phospholipase A2 in 96 pregnant women c cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus 1 : 1600). It was found that the aggravation of CMV infection in pregnant women is accompanied with membrane-destructive phenomena, which are based on the activation of phospholipase A2 and the modification of the phospholipid matrix exhibits decrease of phosphatidylethanolamine (I trimester - by 24%, II trimester - by 16 %, III trimester - by 9 % (p < 0,001)); phosphatidylcholine (I trimester - by 14 %, II trimester - by 16 %, III trimester - 23 % (p < 0,001)); phosphatidylserine (I trimester - by 46 % (p < 0,001), II trimester - by 33 % (p < 0,01), III trimester - by 101 % (p < 0,001)). Increasing the concentration of sphingomyelin (I trimester - by 16 %, II and III trimesters - by 9 %; p < 0,001), lysophosphatidylcholine (I trimester - by 71 %, II trimester - 59 %, III trimester - by 51 % (p < 0,001)) compared with healthy women. Identified changes may be the significant factor in violation of the deformability of cells, red blood cell hemolysis, increased microviscosity blood, and therefore is the cause of fetal hypoxia. |
| format |
article |
| author |
N. A. Ishutina |
| author_facet |
N. A. Ishutina |
| author_sort |
N. A. Ishutina |
| title |
Role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period |
| title_short |
Role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period |
| title_full |
Role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period |
| title_fullStr |
Role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period |
| title_full_unstemmed |
Role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period |
| title_sort |
role of compositional disorders in phospholipids in the pathogenesis of cytomegalovirus infection in the gestation period |
| publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
| publishDate |
2015 |
| url |
https://doaj.org/article/b39744e694c341bdadc8bac65fc618f7 |
| work_keys_str_mv |
AT naishutina roleofcompositionaldisordersinphospholipidsinthepathogenesisofcytomegalovirusinfectioninthegestationperiod |
| _version_ |
1718417092547444736 |