High-throughput single-cell rheology in complex samples by dynamic real-time deformability cytometry

Real-time deformability cytometry (RT-DC) is used for mechanical cell phenotyping but is limited to a single snapshot per cell and can only measure elastic modulus. Here the authors introduce dynamic RT-DC which can measure elasticity and viscosity in single cells by following dynamic cell shape cha...

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Autores principales: Bob Fregin, Fabian Czerwinski, Doreen Biedenweg, Salvatore Girardo, Stefan Gross, Konstanze Aurich, Oliver Otto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/b397de1cf3cb42bea71a934781a7406b
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Sumario:Real-time deformability cytometry (RT-DC) is used for mechanical cell phenotyping but is limited to a single snapshot per cell and can only measure elastic modulus. Here the authors introduce dynamic RT-DC which can measure elasticity and viscosity in single cells by following dynamic cell shape changes.