A Bayesian mixture model for the analysis of allelic expression in single cells

Allele-specific expression at single-cell resolution can reveal stochastic and dynamic features of gene expression in greater detail. The authors propose scBASE, a soft zero-and-one inflated model that improves estimation of cellular allelic proportions by pooling information across cells.

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Autores principales:	Kwangbom Choi, Narayanan Raghupathy, Gary A. Churchill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3986d791d71404d99354a6093a9a7be
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spelling	oai:doaj.org-article:b3986d791d71404d99354a6093a9a7be2021-12-02T16:58:16ZA Bayesian mixture model for the analysis of allelic expression in single cells10.1038/s41467-019-13099-02041-1723https://doaj.org/article/b3986d791d71404d99354a6093a9a7be2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13099-0https://doaj.org/toc/2041-1723Allele-specific expression at single-cell resolution can reveal stochastic and dynamic features of gene expression in greater detail. The authors propose scBASE, a soft zero-and-one inflated model that improves estimation of cellular allelic proportions by pooling information across cells.Kwangbom ChoiNarayanan RaghupathyGary A. ChurchillNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kwangbom Choi Narayanan Raghupathy Gary A. Churchill A Bayesian mixture model for the analysis of allelic expression in single cells
description	Allele-specific expression at single-cell resolution can reveal stochastic and dynamic features of gene expression in greater detail. The authors propose scBASE, a soft zero-and-one inflated model that improves estimation of cellular allelic proportions by pooling information across cells.
format	article
author	Kwangbom Choi Narayanan Raghupathy Gary A. Churchill
author_facet	Kwangbom Choi Narayanan Raghupathy Gary A. Churchill
author_sort	Kwangbom Choi
title	A Bayesian mixture model for the analysis of allelic expression in single cells
title_short	A Bayesian mixture model for the analysis of allelic expression in single cells
title_full	A Bayesian mixture model for the analysis of allelic expression in single cells
title_fullStr	A Bayesian mixture model for the analysis of allelic expression in single cells
title_full_unstemmed	A Bayesian mixture model for the analysis of allelic expression in single cells
title_sort	bayesian mixture model for the analysis of allelic expression in single cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b3986d791d71404d99354a6093a9a7be
work_keys_str_mv	AT kwangbomchoi abayesianmixturemodelfortheanalysisofallelicexpressioninsinglecells AT narayananraghupathy abayesianmixturemodelfortheanalysisofallelicexpressioninsinglecells AT garyachurchill abayesianmixturemodelfortheanalysisofallelicexpressioninsinglecells AT kwangbomchoi bayesianmixturemodelfortheanalysisofallelicexpressioninsinglecells AT narayananraghupathy bayesianmixturemodelfortheanalysisofallelicexpressioninsinglecells AT garyachurchill bayesianmixturemodelfortheanalysisofallelicexpressioninsinglecells
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A Bayesian mixture model for the analysis of allelic expression in single cells

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