Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilised in 15% of cancers that have been associated with mutations in ATRX. Here the authors reveal a functional role of histone demethylases KDM4B in regulating ALT activation.

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Autores principales: M. Udugama, L. Hii, A. Garvie, M. Cervini, B. Vinod, F.-L. Chan, P. P. Das, J. R. Mann, P. Collas, H. P. J. Voon, L. H. Wong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b39a9f1db7b5499c894032806f9966a3
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spelling oai:doaj.org-article:b39a9f1db7b5499c894032806f9966a32021-12-02T17:02:20ZMutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas10.1038/s41467-021-22543-z2041-1723https://doaj.org/article/b39a9f1db7b5499c894032806f9966a32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22543-zhttps://doaj.org/toc/2041-1723Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilised in 15% of cancers that have been associated with mutations in ATRX. Here the authors reveal a functional role of histone demethylases KDM4B in regulating ALT activation.M. UdugamaL. HiiA. GarvieM. CerviniB. VinodF.-L. ChanP. P. DasJ. R. MannP. CollasH. P. J. VoonL. H. WongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
M. Udugama
L. Hii
A. Garvie
M. Cervini
B. Vinod
F.-L. Chan
P. P. Das
J. R. Mann
P. Collas
H. P. J. Voon
L. H. Wong
Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
description Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilised in 15% of cancers that have been associated with mutations in ATRX. Here the authors reveal a functional role of histone demethylases KDM4B in regulating ALT activation.
format article
author M. Udugama
L. Hii
A. Garvie
M. Cervini
B. Vinod
F.-L. Chan
P. P. Das
J. R. Mann
P. Collas
H. P. J. Voon
L. H. Wong
author_facet M. Udugama
L. Hii
A. Garvie
M. Cervini
B. Vinod
F.-L. Chan
P. P. Das
J. R. Mann
P. Collas
H. P. J. Voon
L. H. Wong
author_sort M. Udugama
title Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
title_short Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
title_full Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
title_fullStr Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
title_full_unstemmed Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
title_sort mutations inhibiting kdm4b drive alt activation in atrx-mutated glioblastomas
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b39a9f1db7b5499c894032806f9966a3
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AT lhii mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT agarvie mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT mcervini mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT bvinod mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT flchan mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT ppdas mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT jrmann mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT pcollas mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT hpjvoon mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
AT lhwong mutationsinhibitingkdm4bdrivealtactivationinatrxmutatedglioblastomas
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