Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer

Jara Crear, Kim M Kummer, Thomas J Webster School of Engineering, Brown University, Providence, RI, USA Abstract: Cervical cancer can be treated by surgical resection, chemotherapy, and/or radiation. Titanium biomaterials have been suggested as a tool to help in the local delivery of chemotherapeuti...

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Autores principales:	Crear J, Kummer KM, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b39e255cece446e1adb27a0225c672b4
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spelling	oai:doaj.org-article:b39e255cece446e1adb27a0225c672b42021-12-02T00:43:05ZDecreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer1176-91141178-2013https://doaj.org/article/b39e255cece446e1adb27a0225c672b42013-03-01T00:00:00Zhttp://www.dovepress.com/decreased-cervical-cancer-cell-adhesion-on-nanotubular-titanium-for-th-a12400https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jara Crear, Kim M Kummer, Thomas J Webster School of Engineering, Brown University, Providence, RI, USA Abstract: Cervical cancer can be treated by surgical resection, chemotherapy, and/or radiation. Titanium biomaterials have been suggested as a tool to help in the local delivery of chemotherapeutic agents and/or radiation to cervical cancer sites. However, current titanium medical devices used for treating cervical cancer do not by themselves possess any anticancer properties; such devices act as carriers for pharmaceutical agents or radiation sources and may even allow for the growth of cancer cells. Based on studies, which have demonstrated decreased lung, breast, and bone cancer cell functions on nanostructured compared to nanosmooth polymers, the objective of the present in vitro study was to modify titanium to possess nanotubular surface features and determine cervical cancer cell adhesion after 4 hours. Here, titanium was anodized to possess nanotubular surface features. Results demonstrated the ability to decrease cervical cancer cell adhesion by about a half on nanotubular compared to currently used nanosmooth titanium (without the use of chemotherapeutics or radiation), opening up numerous possibilities for the use of nanotubular titanium in local drug delivery or radiation treatment of cervical cancer. Keywords: cervical cancer, titanium, nanotubular, cell densityCrear JKummer KMWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 995-1001 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Crear J Kummer KM Webster TJ Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer
description	Jara Crear, Kim M Kummer, Thomas J Webster School of Engineering, Brown University, Providence, RI, USA Abstract: Cervical cancer can be treated by surgical resection, chemotherapy, and/or radiation. Titanium biomaterials have been suggested as a tool to help in the local delivery of chemotherapeutic agents and/or radiation to cervical cancer sites. However, current titanium medical devices used for treating cervical cancer do not by themselves possess any anticancer properties; such devices act as carriers for pharmaceutical agents or radiation sources and may even allow for the growth of cancer cells. Based on studies, which have demonstrated decreased lung, breast, and bone cancer cell functions on nanostructured compared to nanosmooth polymers, the objective of the present in vitro study was to modify titanium to possess nanotubular surface features and determine cervical cancer cell adhesion after 4 hours. Here, titanium was anodized to possess nanotubular surface features. Results demonstrated the ability to decrease cervical cancer cell adhesion by about a half on nanotubular compared to currently used nanosmooth titanium (without the use of chemotherapeutics or radiation), opening up numerous possibilities for the use of nanotubular titanium in local drug delivery or radiation treatment of cervical cancer. Keywords: cervical cancer, titanium, nanotubular, cell density
format	article
author	Crear J Kummer KM Webster TJ
author_facet	Crear J Kummer KM Webster TJ
author_sort	Crear J
title	Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer
title_short	Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer
title_full	Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer
title_fullStr	Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer
title_full_unstemmed	Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer
title_sort	decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/b39e255cece446e1adb27a0225c672b4
work_keys_str_mv	AT crearj decreasedcervicalcancercelladhesiononnanotubulartitaniumforthetreatmentofcervicalcancer AT kummerkm decreasedcervicalcancercelladhesiononnanotubulartitaniumforthetreatmentofcervicalcancer AT webstertj decreasedcervicalcancercelladhesiononnanotubulartitaniumforthetreatmentofcervicalcancer
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Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer

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