Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling

Abstract The two hypothalamic neuropeptides oxytocin and melanin concentrating hormone (MCH) share several physiological actions such as the control of maternal care, sexual behavior, and emotions. In this study, we uncover the role for the oxytocin-MCH signaling pathway in mood regulation. We ident...

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Autores principales:	Joseph Phan, Lamees Alhassen, Allan Argelagos, Wedad Alhassen, Benjamin Vachirakorntong, Zitong Lin, Nayna Sanathara, Amal Alachkar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b39fd5a2ec4c48449b184247be55149d
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spelling	oai:doaj.org-article:b39fd5a2ec4c48449b184247be55149d2021-12-02T19:06:33ZMating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling10.1038/s41598-020-70667-x2045-2322https://doaj.org/article/b39fd5a2ec4c48449b184247be55149d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70667-xhttps://doaj.org/toc/2045-2322Abstract The two hypothalamic neuropeptides oxytocin and melanin concentrating hormone (MCH) share several physiological actions such as the control of maternal care, sexual behavior, and emotions. In this study, we uncover the role for the oxytocin-MCH signaling pathway in mood regulation. We identify discrete effects of oxytocin-MCH signaling on depressive behavior and demonstrate that parenting and mating experiences shape these effects. We show that the selective deletion of OXT receptors from MCH neurons increases and decreases depressive behavior in sexually naïve and late postpartum female mice respectively, with no effect on sexually naïve male mice. We demonstrate that both parenting experience and mood-regulating effects of oxytocin-MCH are associated with synaptic plasticity in the reward and fear circuits revealed by the alterations of Arc expressions, which are associated with the depressive behavior. Finally, we uncover the sex-dependent effects of mating on depressive behavior; while the sexual activity reduces the basal levels of depressive behavior in male mice, it reduces in female mice evoked-depression only. We demonstrate that the oxytocin-MCH pathway mediates the effects of sexual activity on depressive behavior. Our data suggest that the oxytocin-MCH pathway can serve as a potential therapeutic target for the treatment of major depression and postpartum mood disorders.Joseph PhanLamees AlhassenAllan ArgelagosWedad AlhassenBenjamin VachirakorntongZitong LinNayna SanatharaAmal AlachkarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph Phan Lamees Alhassen Allan Argelagos Wedad Alhassen Benjamin Vachirakorntong Zitong Lin Nayna Sanathara Amal Alachkar Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
description	Abstract The two hypothalamic neuropeptides oxytocin and melanin concentrating hormone (MCH) share several physiological actions such as the control of maternal care, sexual behavior, and emotions. In this study, we uncover the role for the oxytocin-MCH signaling pathway in mood regulation. We identify discrete effects of oxytocin-MCH signaling on depressive behavior and demonstrate that parenting and mating experiences shape these effects. We show that the selective deletion of OXT receptors from MCH neurons increases and decreases depressive behavior in sexually naïve and late postpartum female mice respectively, with no effect on sexually naïve male mice. We demonstrate that both parenting experience and mood-regulating effects of oxytocin-MCH are associated with synaptic plasticity in the reward and fear circuits revealed by the alterations of Arc expressions, which are associated with the depressive behavior. Finally, we uncover the sex-dependent effects of mating on depressive behavior; while the sexual activity reduces the basal levels of depressive behavior in male mice, it reduces in female mice evoked-depression only. We demonstrate that the oxytocin-MCH pathway mediates the effects of sexual activity on depressive behavior. Our data suggest that the oxytocin-MCH pathway can serve as a potential therapeutic target for the treatment of major depression and postpartum mood disorders.
format	article
author	Joseph Phan Lamees Alhassen Allan Argelagos Wedad Alhassen Benjamin Vachirakorntong Zitong Lin Nayna Sanathara Amal Alachkar
author_facet	Joseph Phan Lamees Alhassen Allan Argelagos Wedad Alhassen Benjamin Vachirakorntong Zitong Lin Nayna Sanathara Amal Alachkar
author_sort	Joseph Phan
title	Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
title_short	Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
title_full	Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
title_fullStr	Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
title_full_unstemmed	Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling
title_sort	mating and parenting experiences sculpture mood-modulating effects of oxytocin-mch signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b39fd5a2ec4c48449b184247be55149d
work_keys_str_mv	AT josephphan matingandparentingexperiencessculpturemoodmodulatingeffectsofoxytocinmchsignaling AT lameesalhassen matingandparentingexperiencessculpturemoodmodulatingeffectsofoxytocinmchsignaling AT allanargelagos matingandparentingexperiencessculpturemoodmodulatingeffectsofoxytocinmchsignaling AT wedadalhassen matingandparentingexperiencessculpturemoodmodulatingeffectsofoxytocinmchsignaling AT benjaminvachirakorntong matingandparentingexperiencessculpturemoodmodulatingeffectsofoxytocinmchsignaling AT zitonglin matingandparentingexperiencessculpturemoodmodulatingeffectsofoxytocinmchsignaling AT naynasanathara matingandparentingexperiencessculpturemoodmodulatingeffectsofoxytocinmchsignaling AT amalalachkar matingandparentingexperiencessculpturemoodmodulatingeffectsofoxytocinmchsignaling
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Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling

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