Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, glios...

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Auteurs principaux: Ting Zou, Lixiong Gao, Yuxiao Zeng, Qiyou Li, Yijian Li, Siyu Chen, Xisu Hu, Xi Chen, Caiyun Fu, Haiwei Xu, Zheng Qin Yin
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/b3a0a613f39d4b1d8b06d83729d56216
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Résumé:Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, gliosis and inflammation.