Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, glios...

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Autores principales: Ting Zou, Lixiong Gao, Yuxiao Zeng, Qiyou Li, Yijian Li, Siyu Chen, Xisu Hu, Xi Chen, Caiyun Fu, Haiwei Xu, Zheng Qin Yin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/b3a0a613f39d4b1d8b06d83729d56216
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spelling oai:doaj.org-article:b3a0a613f39d4b1d8b06d83729d562162021-12-02T16:58:03ZOrganoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents10.1038/s41467-019-08961-02041-1723https://doaj.org/article/b3a0a613f39d4b1d8b06d83729d562162019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08961-0https://doaj.org/toc/2041-1723Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, gliosis and inflammation.Ting ZouLixiong GaoYuxiao ZengQiyou LiYijian LiSiyu ChenXisu HuXi ChenCaiyun FuHaiwei XuZheng Qin YinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ting Zou
Lixiong Gao
Yuxiao Zeng
Qiyou Li
Yijian Li
Siyu Chen
Xisu Hu
Xi Chen
Caiyun Fu
Haiwei Xu
Zheng Qin Yin
Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
description Stem cell transplantation to treat retinal degeneration could be limited by the degenerative microenvironment. Here, the authors show that C-Kit+/SSEA4– progenitor cells enriched from human embryonic stem cell derived retinal organoids protect retinal structure, suppress microglial activation, gliosis and inflammation.
format article
author Ting Zou
Lixiong Gao
Yuxiao Zeng
Qiyou Li
Yijian Li
Siyu Chen
Xisu Hu
Xi Chen
Caiyun Fu
Haiwei Xu
Zheng Qin Yin
author_facet Ting Zou
Lixiong Gao
Yuxiao Zeng
Qiyou Li
Yijian Li
Siyu Chen
Xisu Hu
Xi Chen
Caiyun Fu
Haiwei Xu
Zheng Qin Yin
author_sort Ting Zou
title Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_short Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_full Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_fullStr Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_full_unstemmed Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
title_sort organoid-derived c-kit+/ssea4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/b3a0a613f39d4b1d8b06d83729d56216
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