Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery

Background - The risk of local recurrence in colorectal cancer has been associated with the length of clear distal margin in the specimen taken during original resection. It has been reported that there is significant specimen shrinkage after fixation in formalin. This study is aimed to quantify thi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yiu Ho, Jai Hoff, Andrew May, Clay Renwick
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2020
Materias:	colorectal neoplasm colorectal surgery formalin margins of excision Medicine R
Acceso en línea:	https://doaj.org/article/b3a18209e4054a40b91baa289c8cbc51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b3a18209e4054a40b91baa289c8cbc51
record_format	dspace
spelling	oai:doaj.org-article:b3a18209e4054a40b91baa289c8cbc512021-11-14T08:12:11ZDistal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery2783-243010.30476/acrr.2020.46702https://doaj.org/article/b3a18209e4054a40b91baa289c8cbc512020-06-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_46702_81428cf1d3091800242ae67b55e5ec5d.pdfhttps://doaj.org/toc/2783-2430Background - The risk of local recurrence in colorectal cancer has been associated with the length of clear distal margin in the specimen taken during original resection. It has been reported that there is significant specimen shrinkage after fixation in formalin. This study is aimed to quantify this degree of shrinkage and to investigate the factors for specimen shrinkage. Methods – This research was a single centre prospective study. All adult patients who underwent colorectal surgery for cancer had demographics, surgical details and cancer staging and pathology recorded. Colonic specimens were measured immediately post resection including the total length, the mesenteric length and the distal length from the palpable tumour. Multiple logistic linear regression was applied to identify factors associated with distal margin shrinkage. Results – Right-sided colectomy specimens had an inconsistent degree of shrinkage. Left-sided colectomy specimens showed an average shrinkage of 20% (CI 4% – 36%). The only other factor observed that had statistically significant association on the shrinkage of distal margins in specimens was increasing tumour size. Conclusions - Specimens resected during anterior resection for colorectal cancer have a consistent level of shrinkage. Locally advanced tumours were observed to have an association with specimen distal margin shrinkage, however the mechanism is unclear. This new evidence can assist intra-operative decision making to allow adequate distal margin resection.Yiu HoJai HoffAndrew MayClay RenwickShiraz University of Medical Sciencesarticlecolorectal neoplasmcolorectal surgeryformalinmargins of excisionMedicineRENIranian Journal of Colorectal Research, Vol 8, Iss 2, Pp 75-78 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal neoplasm colorectal surgery formalin margins of excision Medicine R
spellingShingle	colorectal neoplasm colorectal surgery formalin margins of excision Medicine R Yiu Ho Jai Hoff Andrew May Clay Renwick Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery
description	Background - The risk of local recurrence in colorectal cancer has been associated with the length of clear distal margin in the specimen taken during original resection. It has been reported that there is significant specimen shrinkage after fixation in formalin. This study is aimed to quantify this degree of shrinkage and to investigate the factors for specimen shrinkage. Methods – This research was a single centre prospective study. All adult patients who underwent colorectal surgery for cancer had demographics, surgical details and cancer staging and pathology recorded. Colonic specimens were measured immediately post resection including the total length, the mesenteric length and the distal length from the palpable tumour. Multiple logistic linear regression was applied to identify factors associated with distal margin shrinkage. Results – Right-sided colectomy specimens had an inconsistent degree of shrinkage. Left-sided colectomy specimens showed an average shrinkage of 20% (CI 4% – 36%). The only other factor observed that had statistically significant association on the shrinkage of distal margins in specimens was increasing tumour size. Conclusions - Specimens resected during anterior resection for colorectal cancer have a consistent level of shrinkage. Locally advanced tumours were observed to have an association with specimen distal margin shrinkage, however the mechanism is unclear. This new evidence can assist intra-operative decision making to allow adequate distal margin resection.
format	article
author	Yiu Ho Jai Hoff Andrew May Clay Renwick
author_facet	Yiu Ho Jai Hoff Andrew May Clay Renwick
author_sort	Yiu Ho
title	Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery
title_short	Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery
title_full	Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery
title_fullStr	Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery
title_full_unstemmed	Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery
title_sort	distal margin shrinkage factor – a consideration before dividing the specimen in colorectal cancer surgery
publisher	Shiraz University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/b3a18209e4054a40b91baa289c8cbc51
work_keys_str_mv	AT yiuho distalmarginshrinkagefactoraconsiderationbeforedividingthespecimenincolorectalcancersurgery AT jaihoff distalmarginshrinkagefactoraconsiderationbeforedividingthespecimenincolorectalcancersurgery AT andrewmay distalmarginshrinkagefactoraconsiderationbeforedividingthespecimenincolorectalcancersurgery AT clayrenwick distalmarginshrinkagefactoraconsiderationbeforedividingthespecimenincolorectalcancersurgery
_version_	1718429799479771136

Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery

Ejemplares similares