Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart

Abstract Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether omega-3 FA supplementation changes the composition of FAs and their metabolites in the heart and how the changes, if any, exert beneficial effects on cardiac structure and...

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Autores principales: Haruhiro Toko, Hiroyuki Morita, Masanori Katakura, Michio Hashimoto, Toshiyuki Ko, Satoshi Bujo, Yusuke Adachi, Kazutaka Ueda, Haruka Murakami, Masato Ishizuka, Jiaxi Guo, Chunxia Zhao, Takayuki Fujiwara, Hironori Hara, Norifumi Takeda, Eiki Takimoto, Osamu Shido, Mutsuo Harada, Issei Komuro
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b3a55341d22e4566988785eb3ba384b2
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spelling oai:doaj.org-article:b3a55341d22e4566988785eb3ba384b22021-12-02T18:48:22ZOmega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart10.1038/s41598-020-72686-02045-2322https://doaj.org/article/b3a55341d22e4566988785eb3ba384b22020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72686-0https://doaj.org/toc/2045-2322Abstract Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether omega-3 FA supplementation changes the composition of FAs and their metabolites in the heart and how the changes, if any, exert beneficial effects on cardiac structure and function. To clarify these issues, we supplied omega-3 FA to mice exposed to pressure overload, and examined cardiac structure and function by echocardiography and a proportion of FAs and their metabolites by gas chromatography and liquid chromatography-tandem mass spectrometry, respectively. Pressure overload induced cardiac hypertrophy and dysfunction, and reduced concentration of all FAs’ components and increased free form arachidonic acid and its metabolites, precursors of pro-inflammatory mediators in the heart. Omega-3 FA supplementation increased both total and free form of eicosapentaenoic acid, a precursor of pro-resolution mediators and reduced free form arachidonic acid in the heart. Omega-3 FA supplementation suppressed expressions of pro-inflammatory cytokines and the infiltration of inflammatory cells into the heart and ameliorated cardiac dysfunction and fibrosis. These results suggest that omega-3 FA-induced changes of FAs composition in the heart have beneficial effects on cardiac function via regulating inflammation.Haruhiro TokoHiroyuki MoritaMasanori KatakuraMichio HashimotoToshiyuki KoSatoshi BujoYusuke AdachiKazutaka UedaHaruka MurakamiMasato IshizukaJiaxi GuoChunxia ZhaoTakayuki FujiwaraHironori HaraNorifumi TakedaEiki TakimotoOsamu ShidoMutsuo HaradaIssei KomuroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Haruhiro Toko
Hiroyuki Morita
Masanori Katakura
Michio Hashimoto
Toshiyuki Ko
Satoshi Bujo
Yusuke Adachi
Kazutaka Ueda
Haruka Murakami
Masato Ishizuka
Jiaxi Guo
Chunxia Zhao
Takayuki Fujiwara
Hironori Hara
Norifumi Takeda
Eiki Takimoto
Osamu Shido
Mutsuo Harada
Issei Komuro
Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
description Abstract Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether omega-3 FA supplementation changes the composition of FAs and their metabolites in the heart and how the changes, if any, exert beneficial effects on cardiac structure and function. To clarify these issues, we supplied omega-3 FA to mice exposed to pressure overload, and examined cardiac structure and function by echocardiography and a proportion of FAs and their metabolites by gas chromatography and liquid chromatography-tandem mass spectrometry, respectively. Pressure overload induced cardiac hypertrophy and dysfunction, and reduced concentration of all FAs’ components and increased free form arachidonic acid and its metabolites, precursors of pro-inflammatory mediators in the heart. Omega-3 FA supplementation increased both total and free form of eicosapentaenoic acid, a precursor of pro-resolution mediators and reduced free form arachidonic acid in the heart. Omega-3 FA supplementation suppressed expressions of pro-inflammatory cytokines and the infiltration of inflammatory cells into the heart and ameliorated cardiac dysfunction and fibrosis. These results suggest that omega-3 FA-induced changes of FAs composition in the heart have beneficial effects on cardiac function via regulating inflammation.
format article
author Haruhiro Toko
Hiroyuki Morita
Masanori Katakura
Michio Hashimoto
Toshiyuki Ko
Satoshi Bujo
Yusuke Adachi
Kazutaka Ueda
Haruka Murakami
Masato Ishizuka
Jiaxi Guo
Chunxia Zhao
Takayuki Fujiwara
Hironori Hara
Norifumi Takeda
Eiki Takimoto
Osamu Shido
Mutsuo Harada
Issei Komuro
author_facet Haruhiro Toko
Hiroyuki Morita
Masanori Katakura
Michio Hashimoto
Toshiyuki Ko
Satoshi Bujo
Yusuke Adachi
Kazutaka Ueda
Haruka Murakami
Masato Ishizuka
Jiaxi Guo
Chunxia Zhao
Takayuki Fujiwara
Hironori Hara
Norifumi Takeda
Eiki Takimoto
Osamu Shido
Mutsuo Harada
Issei Komuro
author_sort Haruhiro Toko
title Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
title_short Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
title_full Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
title_fullStr Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
title_full_unstemmed Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
title_sort omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b3a55341d22e4566988785eb3ba384b2
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