The Role of Decorin and Biglycan Signaling in Tumorigenesis

The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and pro...

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Autores principales:	Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo, Liliana Schaefer
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	extracellular matrix proteoglycan autophagy inflammation angiogenesis cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b3ab510a619640f0bfc31431f6145b6d
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spelling	oai:doaj.org-article:b3ab510a619640f0bfc31431f6145b6d2021-12-01T15:04:55ZThe Role of Decorin and Biglycan Signaling in Tumorigenesis2234-943X10.3389/fonc.2021.801801https://doaj.org/article/b3ab510a619640f0bfc31431f6145b6d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.801801/fullhttps://doaj.org/toc/2234-943XThe complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and progression. In their soluble forms, decorin and biglycan act as powerful signaling molecules. By receptor-mediated signal transduction, both proteoglycans modulate key processes vital for tumor initiation and progression, such as autophagy, inflammation, cell-cycle, apoptosis, and angiogenesis. Despite of their structural homology, these two proteoglycans interact with distinct cell surface receptors and thus modulate distinct signaling pathways that ultimately affect cancer development. In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and address potential novel therapeutic implications.Valentina DiehlLisa Sophie HuberJonel TrebickaMalgorzata WygreckaRenato V. IozzoLiliana SchaeferFrontiers Media S.A.articleextracellular matrixproteoglycanautophagyinflammationangiogenesiscancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular matrix proteoglycan autophagy inflammation angiogenesis cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	extracellular matrix proteoglycan autophagy inflammation angiogenesis cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Valentina Diehl Lisa Sophie Huber Jonel Trebicka Malgorzata Wygrecka Renato V. Iozzo Liliana Schaefer The Role of Decorin and Biglycan Signaling in Tumorigenesis
description	The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and progression. In their soluble forms, decorin and biglycan act as powerful signaling molecules. By receptor-mediated signal transduction, both proteoglycans modulate key processes vital for tumor initiation and progression, such as autophagy, inflammation, cell-cycle, apoptosis, and angiogenesis. Despite of their structural homology, these two proteoglycans interact with distinct cell surface receptors and thus modulate distinct signaling pathways that ultimately affect cancer development. In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and address potential novel therapeutic implications.
format	article
author	Valentina Diehl Lisa Sophie Huber Jonel Trebicka Malgorzata Wygrecka Renato V. Iozzo Liliana Schaefer
author_facet	Valentina Diehl Lisa Sophie Huber Jonel Trebicka Malgorzata Wygrecka Renato V. Iozzo Liliana Schaefer
author_sort	Valentina Diehl
title	The Role of Decorin and Biglycan Signaling in Tumorigenesis
title_short	The Role of Decorin and Biglycan Signaling in Tumorigenesis
title_full	The Role of Decorin and Biglycan Signaling in Tumorigenesis
title_fullStr	The Role of Decorin and Biglycan Signaling in Tumorigenesis
title_full_unstemmed	The Role of Decorin and Biglycan Signaling in Tumorigenesis
title_sort	role of decorin and biglycan signaling in tumorigenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b3ab510a619640f0bfc31431f6145b6d
work_keys_str_mv	AT valentinadiehl theroleofdecorinandbiglycansignalingintumorigenesis AT lisasophiehuber theroleofdecorinandbiglycansignalingintumorigenesis AT joneltrebicka theroleofdecorinandbiglycansignalingintumorigenesis AT malgorzatawygrecka theroleofdecorinandbiglycansignalingintumorigenesis AT renatoviozzo theroleofdecorinandbiglycansignalingintumorigenesis AT lilianaschaefer theroleofdecorinandbiglycansignalingintumorigenesis AT valentinadiehl roleofdecorinandbiglycansignalingintumorigenesis AT lisasophiehuber roleofdecorinandbiglycansignalingintumorigenesis AT joneltrebicka roleofdecorinandbiglycansignalingintumorigenesis AT malgorzatawygrecka roleofdecorinandbiglycansignalingintumorigenesis AT renatoviozzo roleofdecorinandbiglycansignalingintumorigenesis AT lilianaschaefer roleofdecorinandbiglycansignalingintumorigenesis
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The Role of Decorin and Biglycan Signaling in Tumorigenesis

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