Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

Ma, Hernandez et al develop a 3D culture-transplant system to enable studies of cancer metastasis using patient-derived xenograft (PDX) tumor cells. Using this system, they find that OXPHOS inhibition attenuates the lung metastatic capacity of breast cancer cells and that overexpression of the metab...

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Autores principales:	Dennis Ma, Grace A. Hernandez, Austin E. Y. T. Lefebvre, Hamad Alshetaiwi, Kerrigan Blake, Kushal R. Dave, Maha Rauf, Justice W. Williams, Ryan T. Davis, Katrina T. Evans, Aaron Longworth, Madona Y. G. Masoud, Regis Lee, Robert A. Edwards, Michelle A. Digman, Kai Kessenbrock, Devon A. Lawson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b3b006f381d643aa8b2f8e3e8294d505
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spelling	oai:doaj.org-article:b3b006f381d643aa8b2f8e3e8294d5052021-11-07T12:19:52ZPatient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis10.1038/s42003-021-02596-y2399-3642https://doaj.org/article/b3b006f381d643aa8b2f8e3e8294d5052021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02596-yhttps://doaj.org/toc/2399-3642Ma, Hernandez et al develop a 3D culture-transplant system to enable studies of cancer metastasis using patient-derived xenograft (PDX) tumor cells. Using this system, they find that OXPHOS inhibition attenuates the lung metastatic capacity of breast cancer cells and that overexpression of the metabolic enzyme NME1 increases lung metastasis.Dennis MaGrace A. HernandezAustin E. Y. T. LefebvreHamad AlshetaiwiKerrigan BlakeKushal R. DaveMaha RaufJustice W. WilliamsRyan T. DavisKatrina T. EvansAaron LongworthMadona Y. G. MasoudRegis LeeRobert A. EdwardsMichelle A. DigmanKai KessenbrockDevon A. LawsonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Dennis Ma Grace A. Hernandez Austin E. Y. T. Lefebvre Hamad Alshetaiwi Kerrigan Blake Kushal R. Dave Maha Rauf Justice W. Williams Ryan T. Davis Katrina T. Evans Aaron Longworth Madona Y. G. Masoud Regis Lee Robert A. Edwards Michelle A. Digman Kai Kessenbrock Devon A. Lawson Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
description	Ma, Hernandez et al develop a 3D culture-transplant system to enable studies of cancer metastasis using patient-derived xenograft (PDX) tumor cells. Using this system, they find that OXPHOS inhibition attenuates the lung metastatic capacity of breast cancer cells and that overexpression of the metabolic enzyme NME1 increases lung metastasis.
format	article
author	Dennis Ma Grace A. Hernandez Austin E. Y. T. Lefebvre Hamad Alshetaiwi Kerrigan Blake Kushal R. Dave Maha Rauf Justice W. Williams Ryan T. Davis Katrina T. Evans Aaron Longworth Madona Y. G. Masoud Regis Lee Robert A. Edwards Michelle A. Digman Kai Kessenbrock Devon A. Lawson
author_facet	Dennis Ma Grace A. Hernandez Austin E. Y. T. Lefebvre Hamad Alshetaiwi Kerrigan Blake Kushal R. Dave Maha Rauf Justice W. Williams Ryan T. Davis Katrina T. Evans Aaron Longworth Madona Y. G. Masoud Regis Lee Robert A. Edwards Michelle A. Digman Kai Kessenbrock Devon A. Lawson
author_sort	Dennis Ma
title	Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
title_short	Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
title_full	Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
title_fullStr	Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
title_full_unstemmed	Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
title_sort	patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3b006f381d643aa8b2f8e3e8294d505
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Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

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