Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
Carbapenemase-KPC producing <i>Klebsiella pneumoniae</i> (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a des...
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| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b3b05b01d53d4bbc9ed04158149174b2 |
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| Sumario: | Carbapenemase-KPC producing <i>Klebsiella pneumoniae</i> (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the association of enteric colonization and invasive infections by CP-<i>Kp</i> with one-year mortality. Secondary outcomes were the study of risk factors for colonization and invasive infections by CP-<i>Kp</i>. Results: A total of 5.4% (45/828) of SOT recipients had at least one positive rectal swab for CP-<i>Kp</i>, with most (88.9%) occurring after transplantation. 4.5% (35/828) of patients developed a CP-<i>Kp</i>-related invasive infection, with 68.6% (24/35) being previously colonized. The 1-year mortality was 31.1% in patients with enteric colonization with CP-Kp and, it was 51.4% among patients with CP-<i>Kp</i>-related invasive infections. At univariate analysis, colonization, invasive infections, sepsis, severe sepsis, and septic shock were significantly associated with 1-year mortality. At multivariate analysis, only invasive infections and the combination of sepsis, severe sepsis, or septic shock were significantly associated with 1-year mortality, whereas gastrointestinal colonization was significantly associated with survival. In this population, the 1-year mortality was significantly associated with invasive infections; otherwise, gastrointestinal colonization was not associated with increased 1-year mortality. |
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