Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study

Carbapenemase-KPC producing <i>Klebsiella pneumoniae</i> (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a des...

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Autores principales:	Nicole Pagani, Silvia Corcione, Tommaso Lupia, Silvia Scabini, Claudia Filippini, Roberto Angilletta, Nour Shbaklo, Simone Mornese Pinna, Renato Romagnoli, Luigi Biancone, Rossana Cavallo, Giovanni Di Perri, Paolo Solidoro, Massimo Boffini, Francesco Giuseppe De Rosa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carbapenemase <i>Klebsiella pneumoniae</i> solid organ transplant colonization Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b3b05b01d53d4bbc9ed04158149174b2
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spelling	oai:doaj.org-article:b3b05b01d53d4bbc9ed04158149174b22021-11-25T18:24:45ZCarbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study10.3390/microorganisms91122722076-2607https://doaj.org/article/b3b05b01d53d4bbc9ed04158149174b22021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2272https://doaj.org/toc/2076-2607Carbapenemase-KPC producing <i>Klebsiella pneumoniae</i> (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the association of enteric colonization and invasive infections by CP-<i>Kp</i> with one-year mortality. Secondary outcomes were the study of risk factors for colonization and invasive infections by CP-<i>Kp</i>. Results: A total of 5.4% (45/828) of SOT recipients had at least one positive rectal swab for CP-<i>Kp</i>, with most (88.9%) occurring after transplantation. 4.5% (35/828) of patients developed a CP-<i>Kp</i>-related invasive infection, with 68.6% (24/35) being previously colonized. The 1-year mortality was 31.1% in patients with enteric colonization with CP-Kp and, it was 51.4% among patients with CP-<i>Kp</i>-related invasive infections. At univariate analysis, colonization, invasive infections, sepsis, severe sepsis, and septic shock were significantly associated with 1-year mortality. At multivariate analysis, only invasive infections and the combination of sepsis, severe sepsis, or septic shock were significantly associated with 1-year mortality, whereas gastrointestinal colonization was significantly associated with survival. In this population, the 1-year mortality was significantly associated with invasive infections; otherwise, gastrointestinal colonization was not associated with increased 1-year mortality.Nicole PaganiSilvia CorcioneTommaso LupiaSilvia ScabiniClaudia FilippiniRoberto AngillettaNour ShbakloSimone Mornese PinnaRenato RomagnoliLuigi BianconeRossana CavalloGiovanni Di PerriPaolo SolidoroMassimo BoffiniFrancesco Giuseppe De RosaMDPI AGarticlecarbapenemase<i>Klebsiella pneumoniae</i>solid organ transplantcolonizationBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2272, p 2272 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbapenemase <i>Klebsiella pneumoniae</i> solid organ transplant colonization Biology (General) QH301-705.5
spellingShingle	carbapenemase <i>Klebsiella pneumoniae</i> solid organ transplant colonization Biology (General) QH301-705.5 Nicole Pagani Silvia Corcione Tommaso Lupia Silvia Scabini Claudia Filippini Roberto Angilletta Nour Shbaklo Simone Mornese Pinna Renato Romagnoli Luigi Biancone Rossana Cavallo Giovanni Di Perri Paolo Solidoro Massimo Boffini Francesco Giuseppe De Rosa Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
description	Carbapenemase-KPC producing <i>Klebsiella pneumoniae</i> (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the association of enteric colonization and invasive infections by CP-<i>Kp</i> with one-year mortality. Secondary outcomes were the study of risk factors for colonization and invasive infections by CP-<i>Kp</i>. Results: A total of 5.4% (45/828) of SOT recipients had at least one positive rectal swab for CP-<i>Kp</i>, with most (88.9%) occurring after transplantation. 4.5% (35/828) of patients developed a CP-<i>Kp</i>-related invasive infection, with 68.6% (24/35) being previously colonized. The 1-year mortality was 31.1% in patients with enteric colonization with CP-Kp and, it was 51.4% among patients with CP-<i>Kp</i>-related invasive infections. At univariate analysis, colonization, invasive infections, sepsis, severe sepsis, and septic shock were significantly associated with 1-year mortality. At multivariate analysis, only invasive infections and the combination of sepsis, severe sepsis, or septic shock were significantly associated with 1-year mortality, whereas gastrointestinal colonization was significantly associated with survival. In this population, the 1-year mortality was significantly associated with invasive infections; otherwise, gastrointestinal colonization was not associated with increased 1-year mortality.
format	article
author	Nicole Pagani Silvia Corcione Tommaso Lupia Silvia Scabini Claudia Filippini Roberto Angilletta Nour Shbaklo Simone Mornese Pinna Renato Romagnoli Luigi Biancone Rossana Cavallo Giovanni Di Perri Paolo Solidoro Massimo Boffini Francesco Giuseppe De Rosa
author_facet	Nicole Pagani Silvia Corcione Tommaso Lupia Silvia Scabini Claudia Filippini Roberto Angilletta Nour Shbaklo Simone Mornese Pinna Renato Romagnoli Luigi Biancone Rossana Cavallo Giovanni Di Perri Paolo Solidoro Massimo Boffini Francesco Giuseppe De Rosa
author_sort	Nicole Pagani
title	Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_short	Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_full	Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_fullStr	Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_full_unstemmed	Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_sort	carbapenemase-producing <i>klebsiella pneumoniae</i> colonization and infection in solid organ transplant recipients: a single-center, retrospective study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b3b05b01d53d4bbc9ed04158149174b2
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Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study

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