Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment

Abstract It remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC). Therefore, we enrolled 109,360 patients with peptic ulcer disease and matched for age and sex with 218,720 controls from the Taiwan National Health Insurance Research Databas...

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Autores principales:	Yen-Ting Lu, Chung-Han Hsin, Ying-Chou Lu, Meng-Che Wu, Jing-Yang Huang, Cheng‐Chen Huang, Po-Hui Wang, Shun-Fa Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3b1a8887d2842a6872baa2ed2232e93
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spelling	oai:doaj.org-article:b3b1a8887d2842a6872baa2ed2232e932021-12-02T13:18:02ZRisk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment10.1038/s41598-021-85598-42045-2322https://doaj.org/article/b3b1a8887d2842a6872baa2ed2232e932021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85598-4https://doaj.org/toc/2045-2322Abstract It remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC). Therefore, we enrolled 109,360 patients with peptic ulcer disease and matched for age and sex with 218,720 controls from the Taiwan National Health Insurance Research Database between January 1, 1997 and December 31, 2013.The HNC incidence rate was 1.33-fold higher in the peptic ulcer group than in the control group (7.52 vs. 5.68 per 100,00 person-years; crude relative risk: 1.33; 95% confidence interval [CI]: 1.08–1.63) after > 6 years of follow-up. However, in the peptic ulcer subgroup with H. pylori treatment, HNC risk was not significantly different from that of the control group (crude relative risk: 1.12; 95% CI: 0.86–1.46). Moreover, the population with peptic ulcers had the highest risk of laryngeal and hypopharyngeal cancer (adjusted HR: 2.27 [95% CI: 1.16–4.44] and 2.00 [95% CI, 1.13–3.55]), respectively. This observational study suggested that peptic ulcer disease is associated with an increased incidence of laryngeal and hypopharyngeal cancer and H. pylori treatment may have a role in preventing HNC in patients with peptic ulcer disease.Yen-Ting LuChung-Han HsinYing-Chou LuMeng-Che WuJing-Yang HuangCheng‐Chen HuangPo-Hui WangShun-Fa YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yen-Ting Lu Chung-Han Hsin Ying-Chou Lu Meng-Che Wu Jing-Yang Huang Cheng‐Chen Huang Po-Hui Wang Shun-Fa Yang Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment
description	Abstract It remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC). Therefore, we enrolled 109,360 patients with peptic ulcer disease and matched for age and sex with 218,720 controls from the Taiwan National Health Insurance Research Database between January 1, 1997 and December 31, 2013.The HNC incidence rate was 1.33-fold higher in the peptic ulcer group than in the control group (7.52 vs. 5.68 per 100,00 person-years; crude relative risk: 1.33; 95% confidence interval [CI]: 1.08–1.63) after > 6 years of follow-up. However, in the peptic ulcer subgroup with H. pylori treatment, HNC risk was not significantly different from that of the control group (crude relative risk: 1.12; 95% CI: 0.86–1.46). Moreover, the population with peptic ulcers had the highest risk of laryngeal and hypopharyngeal cancer (adjusted HR: 2.27 [95% CI: 1.16–4.44] and 2.00 [95% CI, 1.13–3.55]), respectively. This observational study suggested that peptic ulcer disease is associated with an increased incidence of laryngeal and hypopharyngeal cancer and H. pylori treatment may have a role in preventing HNC in patients with peptic ulcer disease.
format	article
author	Yen-Ting Lu Chung-Han Hsin Ying-Chou Lu Meng-Che Wu Jing-Yang Huang Cheng‐Chen Huang Po-Hui Wang Shun-Fa Yang
author_facet	Yen-Ting Lu Chung-Han Hsin Ying-Chou Lu Meng-Che Wu Jing-Yang Huang Cheng‐Chen Huang Po-Hui Wang Shun-Fa Yang
author_sort	Yen-Ting Lu
title	Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment
title_short	Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment
title_full	Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment
title_fullStr	Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment
title_full_unstemmed	Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment
title_sort	risk of head and neck cancer in patients with peptic ulcers and the effect of helicobacter pylori treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3b1a8887d2842a6872baa2ed2232e93
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Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment

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