Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies

Over the past 50 years, breast cancer immunotherapy has emerged as an active field of research, generating novel, targeted treatments for the disease. Immunotherapies carry enormous potential to improve survival in breast cancer, particularly for the subtypes carrying the poorest prognoses. Here, we...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chiara Cilibrasi, Panagiotis Papanastasopoulos, Mark Samuels, Georgios Giamas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast cancer immunoediting immune tumour microenvironment immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b3b25a1781634d50a5f35e21acee8ac2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b3b25a1781634d50a5f35e21acee8ac2
record_format	dspace
spelling	oai:doaj.org-article:b3b25a1781634d50a5f35e21acee8ac22021-11-11T17:25:42ZReconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies10.3390/ijms2221120151422-00671661-6596https://doaj.org/article/b3b25a1781634d50a5f35e21acee8ac22021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12015https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Over the past 50 years, breast cancer immunotherapy has emerged as an active field of research, generating novel, targeted treatments for the disease. Immunotherapies carry enormous potential to improve survival in breast cancer, particularly for the subtypes carrying the poorest prognoses. Here, we review the mechanisms by which cancer evades immune destruction as well as the history of breast cancer immunotherapies and recent developments, including clinical trials that have shaped the treatment of the disease with a focus on cell therapies, vaccines, checkpoint inhibitors, and oncolytic viruses.Chiara CilibrasiPanagiotis PapanastasopoulosMark SamuelsGeorgios GiamasMDPI AGarticlebreast cancerimmunoeditingimmune tumour microenvironmentimmunotherapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12015, p 12015 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer immunoediting immune tumour microenvironment immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	breast cancer immunoediting immune tumour microenvironment immunotherapy Biology (General) QH301-705.5 Chemistry QD1-999 Chiara Cilibrasi Panagiotis Papanastasopoulos Mark Samuels Georgios Giamas Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies
description	Over the past 50 years, breast cancer immunotherapy has emerged as an active field of research, generating novel, targeted treatments for the disease. Immunotherapies carry enormous potential to improve survival in breast cancer, particularly for the subtypes carrying the poorest prognoses. Here, we review the mechanisms by which cancer evades immune destruction as well as the history of breast cancer immunotherapies and recent developments, including clinical trials that have shaped the treatment of the disease with a focus on cell therapies, vaccines, checkpoint inhibitors, and oncolytic viruses.
format	article
author	Chiara Cilibrasi Panagiotis Papanastasopoulos Mark Samuels Georgios Giamas
author_facet	Chiara Cilibrasi Panagiotis Papanastasopoulos Mark Samuels Georgios Giamas
author_sort	Chiara Cilibrasi
title	Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies
title_short	Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies
title_full	Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies
title_fullStr	Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies
title_full_unstemmed	Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies
title_sort	reconstituting immune surveillance in breast cancer: molecular pathophysiology and current immunotherapy strategies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b3b25a1781634d50a5f35e21acee8ac2
work_keys_str_mv	AT chiaracilibrasi reconstitutingimmunesurveillanceinbreastcancermolecularpathophysiologyandcurrentimmunotherapystrategies AT panagiotispapanastasopoulos reconstitutingimmunesurveillanceinbreastcancermolecularpathophysiologyandcurrentimmunotherapystrategies AT marksamuels reconstitutingimmunesurveillanceinbreastcancermolecularpathophysiologyandcurrentimmunotherapystrategies AT georgiosgiamas reconstitutingimmunesurveillanceinbreastcancermolecularpathophysiologyandcurrentimmunotherapystrategies
_version_	1718432139684347904

Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies

Ejemplares similares