Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways

ABSTRACT Antimicrobial therapies against cystic fibrosis (CF) lung infections are largely aimed at the traditional, well-studied CF pathogens such as Pseudomonas aeruginosa and Burkholderia cepacia complex, despite the fact that the CF lung harbors a complex and dynamic polymicrobial community. A cl...

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Autores principales:	Rutvij A. Khanolkar, Shawn T. Clark, Pauline W. Wang, David M. Hwang, Yvonne C. W. Yau, Valerie J. Waters, David S. Guttman
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Pseudomonas aeruginosa anaerobic bacteria cystic fibrosis ecological succession microbial ecology microbiome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b3b479ac877c4814a5030151659b0b4d
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spelling	oai:doaj.org-article:b3b479ac877c4814a5030151659b0b4d2021-12-02T18:15:47ZEcological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways10.1128/mSystems.00809-202379-5077https://doaj.org/article/b3b479ac877c4814a5030151659b0b4d2020-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00809-20https://doaj.org/toc/2379-5077ABSTRACT Antimicrobial therapies against cystic fibrosis (CF) lung infections are largely aimed at the traditional, well-studied CF pathogens such as Pseudomonas aeruginosa and Burkholderia cepacia complex, despite the fact that the CF lung harbors a complex and dynamic polymicrobial community. A clinical focus on the dominant pathogens ignores potentially important community-level interactions in disease pathology, perhaps explaining why these treatments are often less effective than predicted based on in vitro testing. A better understanding of the ecological dynamics of this ecosystem may enable clinicians to harness these interactions and thereby improve treatment outcomes. Like all ecosystems, the CF lung microbial community develops through a series of stages, each of which may present with distinct microbial communities that generate unique host-microbe and microbe-microbe interactions, metabolic profiles, and clinical phenotypes. While insightful models have been developed to explain some of these stages and interactions, there is no unifying model to describe how these infections develop and persist. Here, we review current perspectives on the ecology of the CF airway and present the CF Ecological Succession (CFES) model that aims to capture the spatial and temporal complexity of CF lung infection, address current challenges in disease management, and inform the development of ecologically driven therapeutic strategies.Rutvij A. KhanolkarShawn T. ClarkPauline W. WangDavid M. HwangYvonne C. W. YauValerie J. WatersDavid S. GuttmanAmerican Society for MicrobiologyarticlePseudomonas aeruginosaanaerobic bacteriacystic fibrosisecological successionmicrobial ecologymicrobiomeMicrobiologyQR1-502ENmSystems, Vol 5, Iss 6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pseudomonas aeruginosa anaerobic bacteria cystic fibrosis ecological succession microbial ecology microbiome Microbiology QR1-502
spellingShingle	Pseudomonas aeruginosa anaerobic bacteria cystic fibrosis ecological succession microbial ecology microbiome Microbiology QR1-502 Rutvij A. Khanolkar Shawn T. Clark Pauline W. Wang David M. Hwang Yvonne C. W. Yau Valerie J. Waters David S. Guttman Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways
description	ABSTRACT Antimicrobial therapies against cystic fibrosis (CF) lung infections are largely aimed at the traditional, well-studied CF pathogens such as Pseudomonas aeruginosa and Burkholderia cepacia complex, despite the fact that the CF lung harbors a complex and dynamic polymicrobial community. A clinical focus on the dominant pathogens ignores potentially important community-level interactions in disease pathology, perhaps explaining why these treatments are often less effective than predicted based on in vitro testing. A better understanding of the ecological dynamics of this ecosystem may enable clinicians to harness these interactions and thereby improve treatment outcomes. Like all ecosystems, the CF lung microbial community develops through a series of stages, each of which may present with distinct microbial communities that generate unique host-microbe and microbe-microbe interactions, metabolic profiles, and clinical phenotypes. While insightful models have been developed to explain some of these stages and interactions, there is no unifying model to describe how these infections develop and persist. Here, we review current perspectives on the ecology of the CF airway and present the CF Ecological Succession (CFES) model that aims to capture the spatial and temporal complexity of CF lung infection, address current challenges in disease management, and inform the development of ecologically driven therapeutic strategies.
format	article
author	Rutvij A. Khanolkar Shawn T. Clark Pauline W. Wang David M. Hwang Yvonne C. W. Yau Valerie J. Waters David S. Guttman
author_facet	Rutvij A. Khanolkar Shawn T. Clark Pauline W. Wang David M. Hwang Yvonne C. W. Yau Valerie J. Waters David S. Guttman
author_sort	Rutvij A. Khanolkar
title	Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways
title_short	Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways
title_full	Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways
title_fullStr	Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways
title_full_unstemmed	Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways
title_sort	ecological succession of polymicrobial communities in the cystic fibrosis airways
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/b3b479ac877c4814a5030151659b0b4d
work_keys_str_mv	AT rutvijakhanolkar ecologicalsuccessionofpolymicrobialcommunitiesinthecysticfibrosisairways AT shawntclark ecologicalsuccessionofpolymicrobialcommunitiesinthecysticfibrosisairways AT paulinewwang ecologicalsuccessionofpolymicrobialcommunitiesinthecysticfibrosisairways AT davidmhwang ecologicalsuccessionofpolymicrobialcommunitiesinthecysticfibrosisairways AT yvonnecwyau ecologicalsuccessionofpolymicrobialcommunitiesinthecysticfibrosisairways AT valeriejwaters ecologicalsuccessionofpolymicrobialcommunitiesinthecysticfibrosisairways AT davidsguttman ecologicalsuccessionofpolymicrobialcommunitiesinthecysticfibrosisairways
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Ecological Succession of Polymicrobial Communities in the Cystic Fibrosis Airways

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