Topography of retinal recovery processes in humans

Babac E Mazinani, Elke Merx, Niklas Plange, Peter Walter, Gernot F RoesslerRWTH Aachen University, Aachen, GermanyBackground: The purpose of this study was to examine retinal recovery processes topographically by the application of three flash sequences with specific interstimulus interval...

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Autores principales:	Mazinani BE, Merx E, Plange N, Walter P, Roessler GF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b3b614ebdac245bc93eb187623dce6e5
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spelling	oai:doaj.org-article:b3b614ebdac245bc93eb187623dce6e52021-12-02T11:28:18ZTopography of retinal recovery processes in humans1177-5483https://doaj.org/article/b3b614ebdac245bc93eb187623dce6e52014-10-01T00:00:00Zhttp://www.dovepress.com/topography-of-retinal-recovery-processes-in-humans-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Babac E Mazinani, Elke Merx, Niklas Plange, Peter Walter, Gernot F RoesslerRWTH Aachen University, Aachen, GermanyBackground: The purpose of this study was to examine retinal recovery processes topographically by the application of three flash sequences with specific interstimulus intervals.Methods: Twelve healthy subjects underwent multifocal electroretinography with a light-emitting diode stimulator. Every flash sequence consisted of three flashes with 25 msec between the first and the second flash and 35 msec between the second and the third flash. The interval between the third and the first flash of the next step was 85 msec. The interstimulus interval-dependent amplitude reductions of the multifocal electroretinographic response for these three intervals yielded three data points that were used to determine the complete curve of the recovery kinetics.Results: Amplitude reductions were higher with shorter interstimulus intervals. The mean half-life periods of the recovery kinetics for the different concentric rings and all subjects were: ring 1, 29.3±5.9 msec; ring 2, 24.2±6.4 msec; ring 3, 23±4.1 msec; ring 4, 23.1±4.6 msec; and ring 5, 22.3±4.4 msec. The differences between the first and all other rings were statistically significant (P<0.05).Conclusion: The kinetics of the amplitude recovery after short interstimulus intervals showed a spatial distribution, with faster recovery toward the macular periphery.Keywords: multifocal, electroretinography, recovery, LED stimulator, interstimulus intervalMazinani BEMerx EPlange NWalter PRoessler GFDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2133-2139 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mazinani BE Merx E Plange N Walter P Roessler GF Topography of retinal recovery processes in humans
description	Babac E Mazinani, Elke Merx, Niklas Plange, Peter Walter, Gernot F RoesslerRWTH Aachen University, Aachen, GermanyBackground: The purpose of this study was to examine retinal recovery processes topographically by the application of three flash sequences with specific interstimulus intervals.Methods: Twelve healthy subjects underwent multifocal electroretinography with a light-emitting diode stimulator. Every flash sequence consisted of three flashes with 25 msec between the first and the second flash and 35 msec between the second and the third flash. The interval between the third and the first flash of the next step was 85 msec. The interstimulus interval-dependent amplitude reductions of the multifocal electroretinographic response for these three intervals yielded three data points that were used to determine the complete curve of the recovery kinetics.Results: Amplitude reductions were higher with shorter interstimulus intervals. The mean half-life periods of the recovery kinetics for the different concentric rings and all subjects were: ring 1, 29.3±5.9 msec; ring 2, 24.2±6.4 msec; ring 3, 23±4.1 msec; ring 4, 23.1±4.6 msec; and ring 5, 22.3±4.4 msec. The differences between the first and all other rings were statistically significant (P<0.05).Conclusion: The kinetics of the amplitude recovery after short interstimulus intervals showed a spatial distribution, with faster recovery toward the macular periphery.Keywords: multifocal, electroretinography, recovery, LED stimulator, interstimulus interval
format	article
author	Mazinani BE Merx E Plange N Walter P Roessler GF
author_facet	Mazinani BE Merx E Plange N Walter P Roessler GF
author_sort	Mazinani BE
title	Topography of retinal recovery processes in humans
title_short	Topography of retinal recovery processes in humans
title_full	Topography of retinal recovery processes in humans
title_fullStr	Topography of retinal recovery processes in humans
title_full_unstemmed	Topography of retinal recovery processes in humans
title_sort	topography of retinal recovery processes in humans
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b3b614ebdac245bc93eb187623dce6e5
work_keys_str_mv	AT mazinanibe topographyofretinalrecoveryprocessesinhumans AT merxe topographyofretinalrecoveryprocessesinhumans AT plangen topographyofretinalrecoveryprocessesinhumans AT walterp topographyofretinalrecoveryprocessesinhumans AT roesslergf topographyofretinalrecoveryprocessesinhumans
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Topography of retinal recovery processes in humans

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