The Case for an Expanded Concept of Trained Immunity

ABSTRACT Trained immunity was originally proposed as a program of innate immunity memory by innate immunity cells of hematopoietic origin such as the monocytes/macrophages and the NK cells. Here I discuss some old and new data justifying this program and some specific, still unanswered, questions it...

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Autor principal:	Antonio Cassone
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Candida immunity inflammation innate Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b3bbba74fe244828adf5eae1d3db955b
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spelling	oai:doaj.org-article:b3bbba74fe244828adf5eae1d3db955b2021-11-15T16:00:27ZThe Case for an Expanded Concept of Trained Immunity10.1128/mBio.00570-182150-7511https://doaj.org/article/b3bbba74fe244828adf5eae1d3db955b2018-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00570-18https://doaj.org/toc/2150-7511ABSTRACT Trained immunity was originally proposed as a program of innate immunity memory by innate immunity cells of hematopoietic origin such as the monocytes/macrophages and the NK cells. Here I discuss some old and new data justifying this program and some specific, still unanswered, questions it raises regarding the model fungus Candida albicans and the chronic, inflammatory vulvovaginal disease it causes. Building upon this well-established program, the recent reports that epithelial cells of mammals can also acquire memory from previous stimulations, and the apparent intrinsic ability of many living cells from bacteria to mammals to learn from experience, I suggest an expansion of the concept of trained immunity to include all cells of different lineages with the potential of memorizing previous microbial encounters. This expansion would better fit the complexity of innate immunity and the role it plays in infectious and inflammatory diseases.Antonio CassoneAmerican Society for MicrobiologyarticleCandidaimmunityinflammationinnateMicrobiologyQR1-502ENmBio, Vol 9, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida immunity inflammation innate Microbiology QR1-502
spellingShingle	Candida immunity inflammation innate Microbiology QR1-502 Antonio Cassone The Case for an Expanded Concept of Trained Immunity
description	ABSTRACT Trained immunity was originally proposed as a program of innate immunity memory by innate immunity cells of hematopoietic origin such as the monocytes/macrophages and the NK cells. Here I discuss some old and new data justifying this program and some specific, still unanswered, questions it raises regarding the model fungus Candida albicans and the chronic, inflammatory vulvovaginal disease it causes. Building upon this well-established program, the recent reports that epithelial cells of mammals can also acquire memory from previous stimulations, and the apparent intrinsic ability of many living cells from bacteria to mammals to learn from experience, I suggest an expansion of the concept of trained immunity to include all cells of different lineages with the potential of memorizing previous microbial encounters. This expansion would better fit the complexity of innate immunity and the role it plays in infectious and inflammatory diseases.
format	article
author	Antonio Cassone
author_facet	Antonio Cassone
author_sort	Antonio Cassone
title	The Case for an Expanded Concept of Trained Immunity
title_short	The Case for an Expanded Concept of Trained Immunity
title_full	The Case for an Expanded Concept of Trained Immunity
title_fullStr	The Case for an Expanded Concept of Trained Immunity
title_full_unstemmed	The Case for an Expanded Concept of Trained Immunity
title_sort	case for an expanded concept of trained immunity
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/b3bbba74fe244828adf5eae1d3db955b
work_keys_str_mv	AT antoniocassone thecaseforanexpandedconceptoftrainedimmunity AT antoniocassone caseforanexpandedconceptoftrainedimmunity
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The Case for an Expanded Concept of Trained Immunity

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