Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics

Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.

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Detalles Bibliográficos
Autores principales: David C. Earl, P. Brent Ferrell, Nalin Leelatian, Jordan T. Froese, Benjamin J. Reisman, Jonathan M. Irish, Brian O. Bachmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b3bcc8bdbb794beeb2a498e7912fa5bb
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Descripción
Sumario:Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.