Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics

Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.

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Autores principales:	David C. Earl, P. Brent Ferrell, Nalin Leelatian, Jordan T. Froese, Benjamin J. Reisman, Jonathan M. Irish, Brian O. Bachmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3bcc8bdbb794beeb2a498e7912fa5bb
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spelling	oai:doaj.org-article:b3bcc8bdbb794beeb2a498e7912fa5bb2021-12-02T14:38:52ZDiscovery of human cell selective effector molecules using single cell multiplexed activity metabolomics10.1038/s41467-017-02470-82041-1723https://doaj.org/article/b3bcc8bdbb794beeb2a498e7912fa5bb2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02470-8https://doaj.org/toc/2041-1723Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.David C. EarlP. Brent FerrellNalin LeelatianJordan T. FroeseBenjamin J. ReismanJonathan M. IrishBrian O. BachmannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David C. Earl P. Brent Ferrell Nalin Leelatian Jordan T. Froese Benjamin J. Reisman Jonathan M. Irish Brian O. Bachmann Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
description	Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.
format	article
author	David C. Earl P. Brent Ferrell Nalin Leelatian Jordan T. Froese Benjamin J. Reisman Jonathan M. Irish Brian O. Bachmann
author_facet	David C. Earl P. Brent Ferrell Nalin Leelatian Jordan T. Froese Benjamin J. Reisman Jonathan M. Irish Brian O. Bachmann
author_sort	David C. Earl
title	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_short	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_full	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_fullStr	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_full_unstemmed	Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
title_sort	discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b3bcc8bdbb794beeb2a498e7912fa5bb
work_keys_str_mv	AT davidcearl discoveryofhumancellselectiveeffectormoleculesusingsinglecellmultiplexedactivitymetabolomics AT pbrentferrell discoveryofhumancellselectiveeffectormoleculesusingsinglecellmultiplexedactivitymetabolomics AT nalinleelatian discoveryofhumancellselectiveeffectormoleculesusingsinglecellmultiplexedactivitymetabolomics AT jordantfroese discoveryofhumancellselectiveeffectormoleculesusingsinglecellmultiplexedactivitymetabolomics AT benjaminjreisman discoveryofhumancellselectiveeffectormoleculesusingsinglecellmultiplexedactivitymetabolomics AT jonathanmirish discoveryofhumancellselectiveeffectormoleculesusingsinglecellmultiplexedactivitymetabolomics AT brianobachmann discoveryofhumancellselectiveeffectormoleculesusingsinglecellmultiplexedactivitymetabolomics
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Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics

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