Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study

Abstract Metabolic disorders have been separately associated with obstructive sleep apnea syndrome (OSAS) and smoking. However, no study has examined their interactions with metabolic parameters, including insulin resistance and dyslipidemia. To investigate whether the combination of OSAS and smokin...

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Autores principales:	Huaming Zhu, Huajun Xu, Rui Chen, Suru Liu, Yunyan Xia, Yiqun Fu, Xinyi Li, Yingjun Qian, Jianyin Zou, Hongliang Yi, Jian Guan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3bec534c4964730bef0b4acf8e945ec
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spelling	oai:doaj.org-article:b3bec534c4964730bef0b4acf8e945ec2021-12-02T15:05:04ZSmoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study10.1038/s41598-017-08930-x2045-2322https://doaj.org/article/b3bec534c4964730bef0b4acf8e945ec2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08930-xhttps://doaj.org/toc/2045-2322Abstract Metabolic disorders have been separately associated with obstructive sleep apnea syndrome (OSAS) and smoking. However, no study has examined their interactions with metabolic parameters, including insulin resistance and dyslipidemia. To investigate whether the combination of OSAS and smoking results in an additive detriment in metabolic disorder parameters, we enrolled consecutive adult men during 2014–2015. Fasted blood samples were taken to determine glucose, insulin, and lipid levels. A questionnaire including an item on smoking pack-year exposure was administered, and the Epworth Sleepiness Scale and overnight polysomnography were performed. Smokers showed higher levels of glucose, insulin, total cholesterol (TC), triglycerides (TG), and low density lipoprotein-cholesterol (LDL-C), but lower high-density lipoprotein cholesterol (HDL-C) levels, than did non-smokers. In addition, the risks for insulin resistance increased with OSAS severity without fully adjustment. An OSAS × smoking interaction was found in insulin resistance after adjusting for potential confounding factors (p = 0.025). Although the difference was not significant, cessation of cigarette smoking seems to have a little benefit for smoking patients with OSAS. A synergistic effect was observed between smoking and OSAS on metabolic disorder parameters. Cessation of cigarette smoking may experience minor benefit for insulin resistance and lipid metabolism in patients with OSAS.Huaming ZhuHuajun XuRui ChenSuru LiuYunyan XiaYiqun FuXinyi LiYingjun QianJianyin ZouHongliang YiJian GuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huaming Zhu Huajun Xu Rui Chen Suru Liu Yunyan Xia Yiqun Fu Xinyi Li Yingjun Qian Jianyin Zou Hongliang Yi Jian Guan Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study
description	Abstract Metabolic disorders have been separately associated with obstructive sleep apnea syndrome (OSAS) and smoking. However, no study has examined their interactions with metabolic parameters, including insulin resistance and dyslipidemia. To investigate whether the combination of OSAS and smoking results in an additive detriment in metabolic disorder parameters, we enrolled consecutive adult men during 2014–2015. Fasted blood samples were taken to determine glucose, insulin, and lipid levels. A questionnaire including an item on smoking pack-year exposure was administered, and the Epworth Sleepiness Scale and overnight polysomnography were performed. Smokers showed higher levels of glucose, insulin, total cholesterol (TC), triglycerides (TG), and low density lipoprotein-cholesterol (LDL-C), but lower high-density lipoprotein cholesterol (HDL-C) levels, than did non-smokers. In addition, the risks for insulin resistance increased with OSAS severity without fully adjustment. An OSAS × smoking interaction was found in insulin resistance after adjusting for potential confounding factors (p = 0.025). Although the difference was not significant, cessation of cigarette smoking seems to have a little benefit for smoking patients with OSAS. A synergistic effect was observed between smoking and OSAS on metabolic disorder parameters. Cessation of cigarette smoking may experience minor benefit for insulin resistance and lipid metabolism in patients with OSAS.
format	article
author	Huaming Zhu Huajun Xu Rui Chen Suru Liu Yunyan Xia Yiqun Fu Xinyi Li Yingjun Qian Jianyin Zou Hongliang Yi Jian Guan
author_facet	Huaming Zhu Huajun Xu Rui Chen Suru Liu Yunyan Xia Yiqun Fu Xinyi Li Yingjun Qian Jianyin Zou Hongliang Yi Jian Guan
author_sort	Huaming Zhu
title	Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study
title_short	Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study
title_full	Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study
title_fullStr	Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study
title_full_unstemmed	Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study
title_sort	smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: evidence from a large cross-sectional study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b3bec534c4964730bef0b4acf8e945ec
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Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study

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