Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice

Abstract In this study, we examined how urine-borne volatile compounds (UVCs) and darcin of male mice are inherited from parents and interact to modulate the olfactory preferences of females using two inbred strains of mice, C57Bl/6 (C57) and BALB/c (BALB), and their reciprocal hybrids (BC = BALB♀× ...

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Autores principales:	Ying-Juan Liu, Hui-Fen Guo, Jian-Xu Zhang, Yao-Hua Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3c2fe3523db409eb2ef1ddb9ba77b4a
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spelling	oai:doaj.org-article:b3c2fe3523db409eb2ef1ddb9ba77b4a2021-12-02T11:52:38ZQuantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice10.1038/s41598-017-02259-12045-2322https://doaj.org/article/b3c2fe3523db409eb2ef1ddb9ba77b4a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02259-1https://doaj.org/toc/2045-2322Abstract In this study, we examined how urine-borne volatile compounds (UVCs) and darcin of male mice are inherited from parents and interact to modulate the olfactory preferences of females using two inbred strains of mice, C57Bl/6 (C57) and BALB/c (BALB), and their reciprocal hybrids (BC = BALB♀× C57♂; CB = C57♀ × BALB♂). Chemical analysis revealed that the UVCs of C57BL/6 males were quantitatively distinguishable from those of BALB/c males. Darcin was detected in C57 urine, but not in BALB urine. The levels of UVCs and darcin in both BC and CB were intermediate between those of C57 and BALB. Behaviourally, C57 females consistently preferred BALB male urine over C57 or CB males despite that there are trace amounts of darcin in BALB urine. However, the preference for BALB urine disappeared in contact two-choice tests of BALB vs. BC pairs, and restored when recombinant darcin was added to BALB male urine. Our results suggested that both UVCs and darcin in male mice are quantitatively inherited and interact to affect the olfactory preferences of females.Ying-Juan LiuHui-Fen GuoJian-Xu ZhangYao-Hua ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying-Juan Liu Hui-Fen Guo Jian-Xu Zhang Yao-Hua Zhang Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice
description	Abstract In this study, we examined how urine-borne volatile compounds (UVCs) and darcin of male mice are inherited from parents and interact to modulate the olfactory preferences of females using two inbred strains of mice, C57Bl/6 (C57) and BALB/c (BALB), and their reciprocal hybrids (BC = BALB♀× C57♂; CB = C57♀ × BALB♂). Chemical analysis revealed that the UVCs of C57BL/6 males were quantitatively distinguishable from those of BALB/c males. Darcin was detected in C57 urine, but not in BALB urine. The levels of UVCs and darcin in both BC and CB were intermediate between those of C57 and BALB. Behaviourally, C57 females consistently preferred BALB male urine over C57 or CB males despite that there are trace amounts of darcin in BALB urine. However, the preference for BALB urine disappeared in contact two-choice tests of BALB vs. BC pairs, and restored when recombinant darcin was added to BALB male urine. Our results suggested that both UVCs and darcin in male mice are quantitatively inherited and interact to affect the olfactory preferences of females.
format	article
author	Ying-Juan Liu Hui-Fen Guo Jian-Xu Zhang Yao-Hua Zhang
author_facet	Ying-Juan Liu Hui-Fen Guo Jian-Xu Zhang Yao-Hua Zhang
author_sort	Ying-Juan Liu
title	Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice
title_short	Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice
title_full	Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice
title_fullStr	Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice
title_full_unstemmed	Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice
title_sort	quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b3c2fe3523db409eb2ef1ddb9ba77b4a
work_keys_str_mv	AT yingjuanliu quantitativeinheritanceofvolatilepheromonesanddarcinandtheirinteractioninolfactorypreferencesoffemalemice AT huifenguo quantitativeinheritanceofvolatilepheromonesanddarcinandtheirinteractioninolfactorypreferencesoffemalemice AT jianxuzhang quantitativeinheritanceofvolatilepheromonesanddarcinandtheirinteractioninolfactorypreferencesoffemalemice AT yaohuazhang quantitativeinheritanceofvolatilepheromonesanddarcinandtheirinteractioninolfactorypreferencesoffemalemice
_version_	1718395006105944064

Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice

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