Anti-biofilm effects of anthranilate on a broad range of bacteria

Abstract Anthranilate, one of tryptophan degradation products has been reported to interfere with biofilm formation by Pseudomonas aeruginosa. Here, we investigated the effects of anthranilate on biofilm formation by various bacteria and the mechanisms responsible. Anthranilate commonly inhibited bi...

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Autores principales:	Xi-Hui Li, Soo-Kyoung Kim, Joon-Hee Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3ca7c0e10dd44c3b3ba87af6107d446
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spelling	oai:doaj.org-article:b3ca7c0e10dd44c3b3ba87af6107d4462021-12-02T11:52:27ZAnti-biofilm effects of anthranilate on a broad range of bacteria10.1038/s41598-017-06540-12045-2322https://doaj.org/article/b3ca7c0e10dd44c3b3ba87af6107d4462017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06540-1https://doaj.org/toc/2045-2322Abstract Anthranilate, one of tryptophan degradation products has been reported to interfere with biofilm formation by Pseudomonas aeruginosa. Here, we investigated the effects of anthranilate on biofilm formation by various bacteria and the mechanisms responsible. Anthranilate commonly inhibited biofilm formation by P. aeruginosa, Vibrio vulnificus, Bacillus subtilis, Salmonella enterica serovar Typhimurium, and Staphylococcus aureus, and disrupted biofilms preformed by these bacteria. Because anthranilate reduced intracellular c-di-GMP and enhanced swimming and swarming motilities in P. aeruginosa, V. vulnificus, B. subtilis, and S. enterica, it is likely that anthranilate disrupts biofilms by inducing the dispersion of these bacteria. On the other hand, in S. aureus, a non-flagellate bacterium that has no c-di-GMP signaling, anthranilate probably inhibits biofilm formation by reducing slime production. These results suggest that anthranilate has multiple ways for biofilm inhibition. Furthermore, because of its good biofilm inhibitory effects and lack of cytotoxicity to human cells even at high concentration, anthranilate appears to be a promising agent for inhibiting biofilm formation by a broad range of bacteria.Xi-Hui LiSoo-Kyoung KimJoon-Hee LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xi-Hui Li Soo-Kyoung Kim Joon-Hee Lee Anti-biofilm effects of anthranilate on a broad range of bacteria
description	Abstract Anthranilate, one of tryptophan degradation products has been reported to interfere with biofilm formation by Pseudomonas aeruginosa. Here, we investigated the effects of anthranilate on biofilm formation by various bacteria and the mechanisms responsible. Anthranilate commonly inhibited biofilm formation by P. aeruginosa, Vibrio vulnificus, Bacillus subtilis, Salmonella enterica serovar Typhimurium, and Staphylococcus aureus, and disrupted biofilms preformed by these bacteria. Because anthranilate reduced intracellular c-di-GMP and enhanced swimming and swarming motilities in P. aeruginosa, V. vulnificus, B. subtilis, and S. enterica, it is likely that anthranilate disrupts biofilms by inducing the dispersion of these bacteria. On the other hand, in S. aureus, a non-flagellate bacterium that has no c-di-GMP signaling, anthranilate probably inhibits biofilm formation by reducing slime production. These results suggest that anthranilate has multiple ways for biofilm inhibition. Furthermore, because of its good biofilm inhibitory effects and lack of cytotoxicity to human cells even at high concentration, anthranilate appears to be a promising agent for inhibiting biofilm formation by a broad range of bacteria.
format	article
author	Xi-Hui Li Soo-Kyoung Kim Joon-Hee Lee
author_facet	Xi-Hui Li Soo-Kyoung Kim Joon-Hee Lee
author_sort	Xi-Hui Li
title	Anti-biofilm effects of anthranilate on a broad range of bacteria
title_short	Anti-biofilm effects of anthranilate on a broad range of bacteria
title_full	Anti-biofilm effects of anthranilate on a broad range of bacteria
title_fullStr	Anti-biofilm effects of anthranilate on a broad range of bacteria
title_full_unstemmed	Anti-biofilm effects of anthranilate on a broad range of bacteria
title_sort	anti-biofilm effects of anthranilate on a broad range of bacteria
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b3ca7c0e10dd44c3b3ba87af6107d446
work_keys_str_mv	AT xihuili antibiofilmeffectsofanthranilateonabroadrangeofbacteria AT sookyoungkim antibiofilmeffectsofanthranilateonabroadrangeofbacteria AT joonheelee antibiofilmeffectsofanthranilateonabroadrangeofbacteria
_version_	1718395063493459968

Anti-biofilm effects of anthranilate on a broad range of bacteria

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